Technology Process of N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide
There total 8 articles about N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
2.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux
3.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane; water / 20 °C
4.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C
4.2: 0.08 h
With
2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tri-n-butyl(vinyl)tin; sodium hydride; sodium cyanoborohydride; acetic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
2.1: ammonia; methanol / Ra-Ni / 4 h / 20 °C / 1551.49 Torr
3.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C
3.2: 0.08 h
With
methanol; ammonia; sodium cyanoborohydride; caesium carbonate; acetic acid;
Ra-Ni;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C
1.2: 2 h / 0 - 80 °C
1.3: pH 8
2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux
4.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane; water / 20 °C
5.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C
5.2: 0.08 h
With
2,6-dimethylpyridine; hydrogenchloride; sodium periodate; osmium(VIII) oxide; tri-n-butyl(vinyl)tin; sodium hydride; sodium cyanoborohydride; acetic acid; sodium nitrite;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;