BMS-794833

Base Information

• Chemical Name: BMS-794833
• CAS No.: 1174046-72-0
• Molecular Formula: C23H15ClF2N4O3
• Molecular Weight: 468.847
• Mol file: 1174046-72-0.mol

Synonyms:BMS-794833;3-PyridinecarboxaMide, N-[4-[(2-aMino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-

Chemical Property of BMS-794833

Chemical Property:

• Boiling Point: 637.2±55.0 °C(Predicted)
• PKA: 8.79±0.69(Predicted)
• PSA: 114.32000
• Density: 1.508
• LogP: 5.30940
• Solubility.: ≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99% ^*data from raw suppliers

BMS794833 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: BMS-794833 is a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor and it also inhibits Ron (Met family),Axl and Flt-3 with IC50 values <3 nM.

Technology Process of BMS-794833

There total 1 articles about BMS-794833 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-(3-chloro-2-(diphenylmethyleneamino)pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide (1174047-03-0) → BMS 794833 (1174046-72-0)

Guidance literature:

N-(4-(3-chloro-2-(diphenylmethyleneamino)pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; Cooling;

Reference yield:

BMS 794833 (1174046-72-0) + N-[(1,1-dimethylethoxy)carbonyl]-L-alanine chloromethyl ester (150109-42-5) → C32H30ClF2N5O7

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

N-(4-(3-chloro-2-(diphenylmethyleneamino)pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Refernces