4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

Base Information

• Chemical Name: 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
• CAS No.: 452342-67-5
• Molecular Formula: C25H23N5O2
• Molecular Weight: 425.48
• Hs Code.: 2934999090
• UNII: N14114957J
• DSSTox Substance ID: DTXSID70196444
• Nikkaji Number: J3.202.882I
• Wikidata: Q27284368
• Pharos Ligand ID: S4QSUH3JQ1WS
• ChEMBL ID: CHEMBL202887
• Mol file: 452342-67-5.mol

Synonyms:4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide;GW 799388;GW-788388;GW788388

Chemical Property of 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

Chemical Property:

• PSA: 92.79000
• Density: 1.34
• LogP: 4.50040
• Storage Temp.: 2-8°C
• Solubility.: Soluble in DMSO (18 mg/ml with warming)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 425.18517499
• Heavy Atom Count: 32
• Complexity: 605

Purity/Quality:

99% ^*data from raw suppliers

GW788388 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
• Description: GW 788388 is a selective inhibitor of transforming growth factor-β (TGF-β) type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-β stimulates fibrosis in a range of tissues, GW 788388 reduces typical features of fibrosis, including tissue remodeling, increased expression of α-smooth muscle actin and production of collagen I. GW 788388 also blocks TGF-β-mediated production of VEGF by fibroblasts, as well as subsequent angiogenesis in vitro. Inhibition of ALK5 signaling by GW 788388 also induces hypertrophy in femoral growth plates in rats.
• Uses: GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542.