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Technology Process of 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Base Information Edit
  • Chemical Name:1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
  • CAS No.:219580-11-7
  • Molecular Formula:C28H41N7O3
  • Molecular Weight:523.68
  • Hs Code.:2933599590
  • European Community (EC) Number:633-614-8
  • UNII:A4TLL8634Y
  • DSSTox Substance ID:DTXSID30176363
  • Nikkaji Number:J1.019.452K
  • Wikidata:Q27088276
  • Pharos Ligand ID:T39CP5SFXNYL
  • Metabolomics Workbench ID:62786
  • ChEMBL ID:CHEMBL189584
  • Mol file:219580-11-7.mol
1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Synonyms:1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)pyrido(2,3-d)pyrimidin-7-yl)ureea;PD 173074;PD-173074;PD173074

Suppliers and Price of 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • PD 173074
  • 25mg
  • $ 170.00
  • TRC
  • PD 173074
  • 50mg
  • $ 320.00
  • TCI Chemical
  • PD 173074 >95.0%(HPLC)
  • 10mg
  • $ 134.00
  • TCI Chemical
  • PD 173074 >95.0%(HPLC)
  • 50mg
  • $ 400.00
  • Sigma-Aldrich
  • FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
  • 5mg
  • $ 387.00
  • Sigma-Aldrich
  • PD 173074 ≥96% (HPLC), powder
  • 5mg
  • $ 226.00
  • Sigma-Aldrich
  • PD 173074 ≥96% (HPLC), powder
  • 25mg
  • $ 838.00
  • Matrix Scientific
  • 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 95+%
  • 1g
  • $ 1647.00
  • Matrix Scientific
  • 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 95+%
  • 250mg
  • $ 742.00
  • Labseeker
  • PD 173074 98
  • 1g
  • $ 796.00
Total 62 raw suppliers
Chemical Property of 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea Edit
Chemical Property:
  • Appearance/Colour:yellow solid 
  • Melting Point:82-85°C 
  • Refractive Index:1.598 
  • PKA:10.12±0.43(Predicted) 
  • PSA：113.53000 
  • Density:1.163 g/cm3 
  • LogP:5.69980 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: 21 mg/mL 
  • XLogP3:4.5
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:13
  • Exact Mass:523.32708820
  • Heavy Atom Count:38
  • Complexity:690
Purity/Quality:

98%,99%, *data from raw suppliers

PD 173074 *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
  • Description PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1?(IC50?values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3
  • Uses PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM. PD 173074 ar signal-related kinase phosphorylation. A selective FGFR1 and

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