BMS-754807

Base Information

• Chemical Name: BMS-754807
• CAS No.: 1001350-96-4
• Molecular Formula: C23H24FN9O
• Molecular Weight: 461.49
• Mol file: 1001350-96-4.mol

Synonyms:BMS 754807;

Chemical Property of BMS-754807

Chemical Property:

• PSA: 116.13000
• Density: 1.58
• LogP: 3.81610
• Storage Temp.: room temp
• Solubility.: ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥27.75 mg/mL in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

BMS754807 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell proliferation or induces apoptosis in a variety of cancer cells in vitro. It inhibits the growth of tumor xenografts in mice and this effect is often enhanced by combination therapy with other chemotherapeutics. Predictive biomarkers, including elevated IGF-1R expression, for effectiveness of BMS 754807 have been delineated.
• Uses: BMS-754807 has been used in the embryo drug treatment. An IGF-1R inhibitor with an IC50 of 13 nM. BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell proliferation or induces apoptosis in a variety of cancer cells in vitro. It inhibits the growth of tumor xenografts in mice and this effect is often enhanced by combination therapy with other chemotherapeutics. Predictive biomarkers, including elevated IGF-1R expression, for effectiveness of BMS 754807 have been delineated.[Cayman Chemical]