2-Pyridinemethanol,5-chloro-(9CI)

Base Information

• Chemical Name: 2-Pyridinemethanol,5-chloro-(9CI)
• CAS No.: 209526-98-7
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• Mol file: 209526-98-7.mol

Synonyms:2-Pyridinemethanol,5-chloro-(9CI);(5-Chloropyridin-2-yl)methanol;5-Chloropyridine-2-methanol;

Chemical Property of 2-Pyridinemethanol,5-chloro-(9CI)

Chemical Property:

• Vapor Pressure: 0.0285mmHg at 25°C
• Melting Point: 45～47℃
• Refractive Index: 1.572
• Boiling Point: 234.897 °C at 760 mmHg
• PKA: 13.12±0.10(Predicted)
• Flash Point: 95.862 °C
• PSA: 33.12000
• Density: 1.324 g/cm³
• LogP: 1.22730
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(5-Chloropyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinemethanol,5-chloro-(9CI)

There total 1 articles about 2-Pyridinemethanol,5-chloro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyano-5-chloropyridine (89809-64-3) → (5-chloro-2-pyridinyl)methanol (209526-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sulfuric acid / methanol; water / 35 h / Heating / reflux

1.2: pH 6 - 7

2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; In methanol; water;

Reference yield: 49.0%

(5-chloro-2-pyridinyl)methanol (209526-98-7) + 4-hydroxy-1-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]phenyl}pyridin-2(1H)-one (927892-87-3) → 4-[(5-chloropyridin-2-yl)methoxy]-1-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]phenyl}pyridin-2(1H)-one (927892-88-4)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20 ℃;

Reference yield:

(5-chloro-2-pyridinyl)methanol (209526-98-7) → 2-cyano-5-chloropyridine (89809-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / 20 °C

3: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C

With fluorosulfonyl fluoride; hydroxylamine hydrochloride; potassium carbonate; dimethyl sulfoxide;

DOI:10.1002/ejoc.201900478

upstream raw materials:

2-cyano-5-chloropyridine

Downstream raw materials:

5-chloro-pyridin-2-ylmethyl chloride

(5-chloro-2-pyridinyl)methyl methanesulfonate

4-[(5-chloropyridin-2-yl)methoxy]-1-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]phenyl}pyridin-2(1H)-one

2-(bromomethyl)-5-chloropyridine

Refernces