2-butylbenzofuran-5-amine Hydrochloride

Base Information

• Chemical Name: 2-butylbenzofuran-5-amine Hydrochloride
• CAS No.: 526196-90-7
• Molecular Formula: C12H16ClNO
• Molecular Weight: 225.718
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID50431067
• Mol file: 526196-90-7.mol

Synonyms:2-butylbenzofuran-5-amine Hydrochloride;526196-90-7;2-Butyl-5-benzofuranamine Hydrochloride;2-butyl-1-benzofuran-5-amine;hydrochloride;2-butyl-5-benzofuranamine HCl;2-BUTYL-BENZOFURAN-5-YLAMINE HYDROCHLORIDE;2-Butylbenzofuran-5-aminehydrochloride;SCHEMBL5395881;DTXSID50431067;IPNAECRFGLADHK-UHFFFAOYSA-N;AKOS005145693;2-butyl-5-benzo[b]furanamine hydrochloride;FT-0663998;2-BUTYL-1-BENZOFURAN-5-AMINE HYDROCHLORIDE;2-Butyl-1-benzofuran-5-amine--hydrogen chloride (1/1)

Chemical Property of 2-butylbenzofuran-5-amine Hydrochloride

Chemical Property:

• Boiling Point: 317.1 °C at 760 mmHg
• Flash Point: 145.6 °C
• PSA: 39.16000
• LogP: 4.74080
• Solubility.: Methanol, Water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 225.0920418
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

2-Butyl-5-benzofuranamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC1=CC2=C(O1)C=CC(=C2)N.Cl

Technology Process of 2-butylbenzofuran-5-amine Hydrochloride

There total 7 articles about 2-butylbenzofuran-5-amine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

2-n-butyl-2,3-dihydro-3-hydroxy-5-acetamidobenzofuran → 2-n-butyl-5-aminobenzofuran hydrochloride (526196-90-7)

Guidance literature:

With hydrogenchloride; In methanol; water; for 6h; Reflux;

Reference yield:

4-methoxy-aniline (104-94-9) → 2-n-butyl-5-aminobenzofuran hydrochloride (526196-90-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chloroform / 2 h / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / Cooling with ice

2.2: 20 °C

3.1: sodium hydroxide / methanol / 4 h / 65 °C

4.1: sodium tetrahydroborate / 2 h

5.1: hydrogenchloride / water / 6 h / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; sodium hydroxide; In methanol; dichloromethane; chloroform; water;

Reference yield:

4-methoxyacetanilide (51-66-1) → 2-n-butyl-5-aminobenzofuran hydrochloride (526196-90-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / Cooling with ice

1.2: 20 °C

2.1: sodium hydroxide / methanol / 4 h / 65 °C

3.1: sodium tetrahydroborate / 2 h

4.1: hydrogenchloride / water / 6 h / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; sodium hydroxide; In methanol; dichloromethane; water;

upstream raw materials:

2-bromohexanoic acid

2-bromohexanoyl chloride

4-methoxy-aniline

4-methoxyacetanilide

Downstream raw materials:

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide

dronedarone hydrochloride

dronedarone

5-amino-2-n-butyl-3-[4-(3-di-n-butylamino propoxy)benzoyl]benzofuran bisoxalate

Refernces

• 1、 -. "2-butyl-5-substituted aminobenzofuran and its preparation method". . . Retrieved 2017/03/14.