(S)-2-Phenylpyrrolidine hydrochloride

Base Information

• Chemical Name: (S)-2-Phenylpyrrolidine hydrochloride
• CAS No.: 56523-58-1
• Molecular Formula: C₁₀H₁₃N*ClH
• Molecular Weight: 183.681
• Hs Code.: 2933990090
• Mol file: 56523-58-1.mol

Synonyms:(S)-2-Phenylpyrrolidine Hcl

Chemical Property of (S)-2-Phenylpyrrolidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.24190
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-2-phenylpyrrolidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-Phenylpyrrolidine hydrochloride

There total 5 articles about (S)-2-Phenylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-phenyl-pyrrolidine (860640-20-6) → (R)-2-phenylpyrrolidine hydrochloride (56523-58-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1039/b925209f

Reference yield: 84.0%

(S)-1-((R)-2-methylpropane-2-sulfinyl)-2-phenylpyrrolidine (1227798-63-1) → (-)-(S)-2-Phenylpyrrolidine hydrochloride (56523-58-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1039/b925209f

Reference yield:

2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester (174311-02-5) → (R)-2-phenylpyrrolidine hydrochloride (56523-58-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.200902420

upstream raw materials:

(S)-1-((R)-2-methylpropane-2-sulfinyl)-2-phenylpyrrolidine

2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-phenyl-pyrrolidine

Refernces

• 1、 Peterson, Emily A.,Jacobsen, Eric N.. "Enantioselective, thiourea-catalyzed intermolecular addition of indoles to cyclic N-acyl iminium ions". supporting information; experimental part. p. 6328 - 6331. Retrieved 2009/12/01.