Cyclopentanone, 2-(4-methoxyphenyl)-

Base Information

• Chemical Name: Cyclopentanone, 2-(4-methoxyphenyl)-
• CAS No.: 61349-69-7
• Molecular Formula: C11H11FO2
• Molecular Weight: 190.242
• Mol file: 61349-69-7.mol

Synonyms:

Chemical Property of Cyclopentanone, 2-(4-methoxyphenyl)-

Chemical Property:

• Boiling Point: 318.686 °C at 760 mmHg
• Flash Point: 146.536 °C
• Density: 1.294 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanone, 2-(4-methoxyphenyl)-

There total 20 articles about Cyclopentanone, 2-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(4-methoxyphenyl)cyclopentanol (933674-44-3) → (±)-2-(4-methoxyphenyl)cyclopentan-1-one (61349-69-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1055/s-0029-1219340

Reference yield: 78.0%

2-(4-methoxyphenyl)cyclobutan-1-one (70106-27-3) + diazomethyl-trimethyl-silane (18107-18-1) → (±)-2-(4-methoxyphenyl)cyclopentan-1-one (61349-69-7) + 3-(4-methoxyphenyl)cyclopentanone (116526-34-2)

Guidance literature:

2-(4-methoxyphenyl)cyclobutan-1-one; diazomethyl-trimethyl-silane; With scandium tris(trifluoromethanesulfonate); In hexane; dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; water; In hexane; dichloromethane; at 23 ℃; for 0.5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol101136a

Reference yield: 77.0%

allyl 1-(4-methoxyphenyl)-2-oxocyclopentanecarboxylate → (±)-2-(4-methoxyphenyl)cyclopentan-1-one (61349-69-7)

Guidance literature:

With formic acid; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In 1,4-dioxane; at 40 ℃; for 10h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo5014806

upstream raw materials:

4-(2,3-epoxy-cyclopentyl)-anisole

(E)-3-Ureido-but-2-enoic acid ethyl ester

1-(N-morpholino)cyclopent-1-ene

4-methoxyphenyllead(IV) triacetate

Downstream raw materials:

2-(4-methoxyphenyl)-2-<2-(dimethylamino)ethyl>cyclopentanone hydrobromide

C₁₆H₂₀O₃

(-)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-one

(2S,3S)-2-(4-methoxyphenyl)-2-(2-nitro-1-phenylethyl)cyclopentanone

Refernces

• 1、 Zhou, Lin,Liu, Xiaohua,Ji, Jie,Zhang, Yuheng,Wu, Wangbin,Liu, Yangbin,Lin, Lili,Feng, Xiaoming. "Regio- and enantioselective Baeyer-Villiger oxidation: Kinetic resolution of racemic 2-substituted cyclopentanones". . p. 3938 - 3941. Retrieved 2014/08/18.
• 2、 Macleod, Fraser,Lang, Stuart,Murphy, John A.. "The 2-(2-Azidoethyl)cycloalkanone strategy for bridged amides and medium-sized cyclic amine derivatives in the Aubé-Schmidt reaction". supporting information; experimental part. p. 529 - 534. Retrieved 2010/10/02.