4-METHOXYPHENOXYACETONITRILE

Base Information

• Chemical Name: 4-METHOXYPHENOXYACETONITRILE
• CAS No.: 22446-12-4
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.176
• Hs Code.: 2926909090
• Mol file: 22446-12-4.mol

Synonyms:Acetonitrile,(4-methoxyphenoxy)- (9CI); Acetonitrile, (p-methoxyphenoxy)- (8CI);(4-Methoxyphenoxy)acetonitrile; (p-Methoxyphenoxy)acetonitrile

Chemical Property of 4-METHOXYPHENOXYACETONITRILE

Chemical Property:

• Vapor Pressure: 0.00169mmHg at 25°C
• Refractive Index: 1.5270
• Boiling Point: 293.8°Cat760mmHg
• Flash Point: 122.1°C
• PSA: 42.25000
• Density: 1.107g/cm³
• LogP: 1.59758

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Methoxyphenoxy)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: Xn:Harmful
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It finds it application in the synthesis of α-aryloxy-2,4-dihydroxyacetophenone 4-O-β-D-glucopyranosides and their conversion into 3-aryloxy-7-glucosyloxychromones.

Technology Process of 4-METHOXYPHENOXYACETONITRILE

There total 6 articles about 4-METHOXYPHENOXYACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxy-phenol (150-76-5) + acetonitrile (75-05-8,26809-02-9) → 2-(4-methoxyphenoxy)acetonitrile (22446-12-4)

Guidance literature:

With 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane; sodium hydride; at 50 ℃;

DOI:10.1039/c5ra02242h

Reference yield: 88.2%

4-methoxy-phenol (150-76-5) + cyanomethyl bromide (590-17-0) → 2-(4-methoxyphenoxy)acetonitrile (22446-12-4)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1021/co400142t

Reference yield: 87.0%

chloroacetonitrile (107-14-2) + 4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)acetonitrile (22446-12-4)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/ol035223j

upstream raw materials:

chloroacetonitrile

4-methoxy-phenol

iodoacetonitrile

cyanomethyl bromide

Downstream raw materials:

Isonicotinic acid [1-amino-2-(4-methoxy-phenoxy)-eth-(E)-ylidene]-hydrazide

2-(4-methoxy-phenoxy)-thioacetamide

7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one

1-(2,4-dihydroxy-5-propylphenyl)-2-(4-methoxyphenoxy)ethanone

Refernces

• 1、 -. "SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS". Page/Page column 34; 52. . Retrieved 2015/06/03.
• 2、 Yu, Guanping,Kuo, David,Shoham, Menachem,Viswanathan, Rajesh. "Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa". supporting information. p. 85 - 91. Retrieved 2014/03/21.