4-Fluoromethylpiperidine

Base Information

• Chemical Name: 4-Fluoromethylpiperidine
• CAS No.: 259143-04-9
• Molecular Formula: C6H12FN
• Molecular Weight: 117.166
• Hs Code.: 2933399090
• Mol file: 259143-04-9.mol

Synonyms:4-Fluoromethylpiperidine;4-(fluoromethyl)piperidine hydrochloride

Chemical Property of 4-Fluoromethylpiperidine

Chemical Property:

• Boiling Point: 149.617 °C at 760 mmHg
• Flash Point: 44.287 °C
• PSA: 12.03000
• Density: 0.908 g/cm³
• LogP: 1.28430

Purity/Quality:

98%Min ^*data from raw suppliers

4-Fluoromethylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoromethylpiperidine

There total 9 articles about 4-Fluoromethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl 4-(fluoromethyl)piperidine-1-carboxylate → 4-piperidinemethylfluoride (259143-04-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 15h;

DOI:10.1002/bkcs.12254

Reference yield: 95.0%

4-(fluoromethyl)-piperidine trifluoroacetate (1257300-07-4) → 4-piperidinemethylfluoride (259143-04-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1016/j.ejmech.2021.113214

Reference yield:

tert-butyl 4-(fluoromethyl)piperidine-1-carboxylate (259143-03-8) → 4-piperidinemethylfluoride (259143-04-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 0.166667h;

DOI:10.1002/(SICI)1099-1344(19991230)42:13<1289::AID-JLCR287>3.0.CO;2-C

upstream raw materials:

tert-butyl 4-(fluoromethyl)piperidine-1-carboxylate

4-piperidinemethanol

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

Downstream raw materials:

4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

Refernces

• 1、 La, Minh Thanh,Jeong, Byung-Hoon,Kim, Hee-Kwon. "Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study". . p. 740 - 743. Retrieved 2021/03/16.