Ethyl2,2-difluoro-2-(thiophen-3-yl)acetate

Base Information

• Chemical Name: Ethyl2,2-difluoro-2-(thiophen-3-yl)acetate
• CAS No.: 1245643-36-0
• Molecular Formula: C8H8F2O2S
• Molecular Weight: 206.2097
• Mol file: 1245643-36-0.mol

Synonyms:Ethyl difluoro(3-thienyl)acetate;

Chemical Property of Ethyl2,2-difluoro-2-(thiophen-3-yl)acetate

Chemical Property:

• Boiling Point: 238.864 °C at 760 mmHg
• Flash Point: 98.262 °C
• PSA: 54.54000
• Density: 1.289 g/cm³
• LogP: 2.40300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl2,2-difluoro-2-(thiophen-3-yl)acetate

There total 2 articles about Ethyl2,2-difluoro-2-(thiophen-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-thienyl iodide (10486-61-0) + α-(trimethylsilyl)difluoroacetic acid ethyl ester (205865-67-4) → 2,2-Difluoro-2-(thiophen-3-yl)acetic acid ethyl ester (1245643-36-0)

Guidance literature:

With potassium fluoride; copper(l) iodide; In dimethyl sulfoxide; at 60 ℃; for 15h; Inert atmosphere; Schlenk technique;

Reference yield:

thiophene (188290-36-0,8014-23-1,25233-34-5) + α-(trimethylsilyl)difluoroacetic acid ethyl ester (205865-67-4) → 2,2-Difluoro-2-(thiophen-3-yl)acetic acid ethyl ester (1245643-36-0) + ethyl α,α-difluoro-α-[2-(thienyl)]acetate (294182-00-6)

Guidance literature:

With potassium fluoride; silver trifluoromethanesulfonate; In dichloromethane; at 85 ℃; for 24h; Overall yield = 83 %; Overall yield = 85.6 mg; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201600770

upstream raw materials:

thiophene

α-(trimethylsilyl)difluoroacetic acid ethyl ester

3-thienyl iodide

Refernces

• 1、 -. "Manufacturing method of making heteroarylacetic compd. defluoromethyl". Paragraph 0129-0131. . Retrieved 2018/10/03.