3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline

Base Information

• Chemical Name: 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline
• CAS No.: 74097-58-8
• Molecular Formula: C₁₇H₂₆N₂O₃S
• Molecular Weight: 338.471
• Mol file: 74097-58-8.mol

Synonyms:

Chemical Property of 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline

There total 6 articles about 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-butan-2-one (563-80-4) → 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline (74097-58-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) N-methylaniline, methylmagnesium bromide / diethylether, 2h

2: H₂SO₄ / 12 h / Ambient temperature

3: NaOH, H₂O₂ / methanol / 18 h

4: 73 percent / p-toluenesulfonic acid / tetrahydrofuran / 8 h / Heating

5: 100 percent / chromic acid (Jones reagent) / acetone / 0.5 h

6: NaBH₄ / ethanol / 1 h

With sodium hydroxide; sodium tetrahydroborate; Jones reagent; sulfuric acid; methylmagnesium bromide; dihydrogen peroxide; toluene-4-sulfonic acid; N-methylaniline; In tetrahydrofuran; methanol; ethanol; acetone;

DOI:10.1021/jo01305a007

Reference yield:

2,5,6-trimethylhept-4-en-3-one (16466-21-0) → 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline (74097-58-8)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH, H₂O₂ / methanol / 18 h

2: 73 percent / p-toluenesulfonic acid / tetrahydrofuran / 8 h / Heating

3: 100 percent / chromic acid (Jones reagent) / acetone / 0.5 h

4: NaBH₄ / ethanol / 1 h

With sodium hydroxide; sodium tetrahydroborate; Jones reagent; dihydrogen peroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; acetone;

DOI:10.1021/jo01305a007

Reference yield:

5-hydroxy-2,5,6-trimethyl-heptan-3-one (54862-89-4) → 3,c-5-diisopropyl-r-4-hydroxy-5-methyl-1-p-tosyl-2-pyrazoline (74097-58-8)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂SO₄ / 12 h / Ambient temperature

2: NaOH, H₂O₂ / methanol / 18 h

3: 73 percent / p-toluenesulfonic acid / tetrahydrofuran / 8 h / Heating

4: 100 percent / chromic acid (Jones reagent) / acetone / 0.5 h

5: NaBH₄ / ethanol / 1 h

With sodium hydroxide; sodium tetrahydroborate; Jones reagent; sulfuric acid; dihydrogen peroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; acetone;

DOI:10.1021/jo01305a007

upstream raw materials:

3,5-diisopropyl-5-methyl-1-p-tosyl-2-pyrazolin-4-one

3-methyl-butan-2-one

2,5,6-trimethylhept-4-en-3-one

5-hydroxy-2,5,6-trimethyl-heptan-3-one

Refernces