3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE

Base Information

• Chemical Name: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE
• CAS No.: 104774-87-0
• Molecular Formula: C10H12F3N
• Molecular Weight: 203.207
• Mol file: 104774-87-0.mol

Synonyms:RARECHEM AL BW 1078;3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE;3-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-1-AMINE;3-(TrifluoroMethyl)-benzenepropanaMine

Chemical Property of 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE

Chemical Property:

• Boiling Point: 222.2±40.0 °C(Predicted)
• PKA: 10.20±0.10(Predicted)
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3-[3-(Trifluoromethyl)phenyl]propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE

There total 11 articles about 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

3-[3-(trifluoromethyl)phenyl]-2-propenenitrile (95728-83-9) → 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine (104774-87-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 50 ℃; for 5h; under 22502.3 Torr;

Reference yield: 65.0%

3-(3-trifluoromethyl-phenyl)-propionic acid amide (535-53-5) → 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine (104774-87-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/j.tetlet.2004.09.063

Reference yield:

3-(3-(trifluoromethyl)phenyl)propanenitrile (95096-06-3) → 3‐[3‐(trifluoromethyl)phenyl]propan‐1‐amine (104774-87-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2019.115178

upstream raw materials:

T₀₅₀₂-9046

3-(3-trifluoromethyl-phenyl)-propionic acid amide

trans-3-(trifluoromethyl)cinnamoyl chloride

(E)-3-(3-(trifluoromethyl)phenyl)acrylamide

Downstream raw materials:

cinacalcet hydrochloride

cinacalcet

C₂₂H₂₂F₃N

[1-(7,8-dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine

Refernces

• 1、 Xing, Gang,Zhi, Zhengxing,Yi, Ce,Zou, Jitian,Jing, Xuefeng,Yiu-Ho Woo, Anthony,Lin, Bin,Pan, Li,Zhang, Yuyang,Cheng, Maosheng. "8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study". . . Retrieved 2021/07/19.
• 2、 -. "Hydrochloric acid [...] and its intermediate synthesis method". . . Retrieved 2017/06/29.