2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol

Base Information

• Chemical Name: 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol
• CAS No.: 956905-27-4
• Molecular Formula: C19H16N8O
• Molecular Weight: 372.3833
• UNII: CYJ9ATV1IJ
• ChEMBL ID: CHEMBL2001019
• DSSTox Substance ID: DTXSID401026097
• Metabolomics Workbench ID: 153752
• NCI Thesaurus Code: C78483
• Nikkaji Number: J2.735.434C
• Pharos Ligand ID: CZP7Y4JSTXHX
• Wikidata: Q27163274
• Mol file: 956905-27-4.mol

Synonyms:2-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol;PF 04217903;PF-04217903;PF04217903

Chemical Property of 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol

Chemical Property:

• Vapor Pressure: 1.21E-21mmHg at 25°C
• Refractive Index: 1.806
• Boiling Point: 718.1 °C at 760 mmHg
• PKA: 14.31±0.10(Predicted)
• Flash Point: 388.1 °C
• PSA: 107.43000
• Density: 1.53 g/cm³
• LogP: 1.67360
• Solubility.: insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 372.14470716
• Heavy Atom Count: 28
• Complexity: 524

Purity/Quality:

98% min ^*data from raw suppliers

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
• Recent ClinicalTrials: A Study of PF-04217903 in Patients With Advanced Cancer
• Uses: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol is a potential targets for protein kinase inhibitors on the regulation of autophagy. A potent and selective c-MET receptor tyrosine kinase. Potent c-MET inhibitor.