2-Hydrazinyl-5-Methylpyridine

Base Information

• Chemical Name: 2-Hydrazinyl-5-Methylpyridine
• CAS No.: 4931-01-5
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60399987
• Nikkaji Number: J2.441.814F
• Wikidata: Q72482833
• Mol file: 4931-01-5.mol

Synonyms:2-Hydrazinyl-5-Methylpyridine;4931-01-5;(5-methylpyridin-2-yl)hydrazine;2-Hydrazino-5-methylpyridine;(5-METHYL-PYRIDIN-2-YL)-HYDRAZINE;1-(5-METHYLPYRIDIN-2-YL)HYDRAZINE;2-Hydrazino-5-methylpyridine, 90per cent;5-Methyl-2-pyridylhydrazine;2-Hydrazino-5-methylpyridine, 90%;2(1H)-Pyridinone, 5-methyl-, hydrazone;5-methylpyrid-2-ylhydrazine;SCHEMBL248181;SCHEMBL16216066;DTXSID60399987;PNVWNMCAGZBUNK-UHFFFAOYSA-N;AMY29076;1-(5-Methyl-2-pyridinyl)hydrazine;MFCD03425577;AKOS000155207;SB53498;BL010291;BS-13012;FT-0669255;EN300-58162;(5-methyl-pyridin-2-yl)-hydrazine, AldrichCPR;A913985;F8887-6537

Chemical Property of 2-Hydrazinyl-5-Methylpyridine

Chemical Property:

• Vapor Pressure: 0.00371mmHg at 25°C
• Melting Point: 67-68oC
• Refractive Index: 1.632
• Boiling Point: 280.7 °C at 760 mmHg
• PKA: 9.85±0.70(Predicted)
• Flash Point: 123.6 °C
• PSA: 50.94000
• Density: 1.166 g/cm³
• LogP: 1.44890
• Storage Temp.: -86°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

99% ^*data from raw suppliers

2-Hydrazino-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=C1)NN
• Uses: 2-Hydrazino-5-methylpyridine is used as a herbicide

Technology Process of 2-Hydrazinyl-5-Methylpyridine

There total 5 articles about 2-Hydrazinyl-5-Methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-Bromo-5-methylpyridine (3510-66-5) → 2-hydrazinyl-5-methylpyridine (4931-01-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 105 ℃; for 120h;

DOI:10.1016/j.ejmech.2021.113232

Reference yield: 67.0%

2-chloro-5-methylpyridine (18368-64-4) → 2-hydrazinyl-5-methylpyridine (4931-01-5)

Guidance literature:

With hydrazine hydrate; at 150 ℃; for 16h;

Reference yield: 54.9%

2-fluoro-5-methylpyridine (2369-19-9) → 2-hydrazinyl-5-methylpyridine (4931-01-5)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 15h; Inert atmosphere;

upstream raw materials:

2-Bromo-5-methylpyridine

2-chloro-5-methylpyridine

2-fluoro-5-methylpyridine

Downstream raw materials:

6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

C₁₉H₁₄F₆N₆O

C₂₂H₁₆Cl₂F₃N₇

C₂₇H₂₄Cl₂F₃N₇O₂

Refernces

• 1、 Akporji, Nnamdi,Braga, Felipe C.,Gabriel, Christopher M.,Landstrom, Evan B.,Lee, Nicholas R.,Lipshutz, Bruce H.. "One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis". supporting information. . Retrieved 2020/09/02.
• 2、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 0630-0632; 0635-0637. . Retrieved 2020/01/04.