2-Fluoro-5-hydrazinylpyridine

Base Information

• Chemical Name: 2-Fluoro-5-hydrazinylpyridine
• CAS No.: 940958-93-0
• Molecular Formula: C5H6FN3
• Molecular Weight: 127.121
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30695105
• Wikidata: Q72479884
• Mol file: 940958-93-0.mol

Synonyms:2-Fluoro-5-hydrazinylpyridine;940958-93-0;(6-fluoropyridin-3-yl)hydrazine;2-Fluoro-5-hydrazinopyridine;(6-fluoro-pyridin-3-yl)-hydrazine;SCHEMBL540867;2-fluoro-5-hydrazino-pyridine;DTXSID30695105;HZFHFNYJGVMRFE-UHFFFAOYSA-N;(6-Fluoropyridin-3-yl)-hydrazine;MFCD11848415;AKOS006336940;AC-23321;PS-10344;FT-0729931;EN300-1867847

Chemical Property of 2-Fluoro-5-hydrazinylpyridine

Chemical Property:

• Boiling Point: 280℃
• Flash Point: 123℃
• PSA: 50.94000
• Density: 1.359
• LogP: 1.27960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 127.05457537
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-5-hydrazinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1NN)F

Technology Process of 2-Fluoro-5-hydrazinylpyridine

There total 2 articles about 2-Fluoro-5-hydrazinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-fluoro-5-aminopyridine (1827-27-6) → 2-fluoro-5-hydrazinylpyridine (940958-93-0)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; sodium nitrite;

DOI:10.1016/j.bmcl.2010.09.095

Reference yield:

→ 2-fluoro-5-hydrazinylpyridine (940958-93-0)

Guidance literature:

Reference yield: 76.0%

2-fluoro-5-hydrazinylpyridine (940958-93-0) + benzoic acid (65-85-0,8013-63-6) → N'-(6-fluoropyridin-3-yl)benzohydrazide

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

upstream raw materials:

2-fluoro-5-aminopyridine

Refernces

• 1、 Thomae, David,Jeanty, Matthieu,Coste, Jerome,Guillaumet, Gerald,Suzenet, Franck. "Extending the scope of the aza-Fischer synthesis of 4- and 6-azaindoles". . p. 3328 - 3336. Retrieved 2013/07/05.
• 2、 -. "STEROIDAL [3, 2-C] PYRAZOLE COMPOUNDS, WITH GLUCOCORTICOID ACTIVITY". Page/Page column 80-81. . Retrieved 2009/05/29.