2-Amino-5-bromoisonicotinic acid

Base Information

• Chemical Name: 2-Amino-5-bromoisonicotinic acid
• CAS No.: 1000339-23-0
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.0201
• Hs Code.: 2933399090
• Mol file: 1000339-23-0.mol

Synonyms:2-Amino-5-bromo-4-pyridinecarboxylic acid;

Chemical Property of 2-Amino-5-bromoisonicotinic acid

Chemical Property:

• Boiling Point: 464.1 °C at 760 mmHg
• PKA: 1.16±0.10(Predicted)
• Flash Point: 234.5 °C
• PSA: 76.21000
• Density: 1.909 g/cm³
• LogP: 1.70570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-bromoisonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-bromoisonicotinic acid

There total 1 articles about 2-Amino-5-bromoisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8) → C6H5BrN2O2 (1000339-23-0)

Guidance literature:

methyl 2-amino-5-bromopyridine-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 ℃; pH=6;

Reference yield:

C6H5BrN2O2 (1000339-23-0) → C20H19BrFN3O4 (1374233-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / 6 h / 90 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 42 h / 80 °C / Inert atmosphere

2.2: 0.25 h / 0 °C

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

C6H5BrN2O2 (1000339-23-0) → C15H11BrFN3O2 (1374233-71-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / 6 h / 90 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 42 h / 80 °C / Inert atmosphere

2.2: 0.25 h / 0 °C

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-amino-5-bromo-pyridine-4-carboxylate

Downstream raw materials:

C₂₀H₁₉BrFN₃O₄

C₁₅H₁₁BrFN₃O₂

C₁₇H₁₅BrFN₃O₆S₂

C₁₆H₁₃BrFN₃O₄S

Refernces