Chk2 Inhibitor II

Base Information

• Chemical Name: Chk2 Inhibitor II
• CAS No.: 516480-79-8
• Molecular Formula: C20H14ClN3O2
• Molecular Weight: 363.803
• NSC Number: 741899
• DSSTox Substance ID: DTXSID40433479
• Nikkaji Number: J3.354.695E
• Wikidata: Q27075966
• Pharos Ligand ID: BJZ9SXYJNGYK
• ChEMBL ID: CHEMBL179583
• Mol file: 516480-79-8.mol

Synonyms:2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide;CHK2iII compound

Chemical Property of Chk2 Inhibitor II

Chemical Property:

• Appearance/Colour: Tan solid
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.703
• Boiling Point: 637.097 °C at 760 mmHg
• PKA: 10.40±0.10(Predicted)
• Flash Point: 339.104 °C
• PSA: 81.99000
• Density: 1.391 g/cm³
• LogP: 5.65870
• Storage Temp.: 2-8°C
• Solubility.: DMSO: 18 mg/mL
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 363.0774544
• Heavy Atom Count: 26
• Complexity: 489

Purity/Quality:

98%Min ^*data from raw suppliers

Chk2 Inhibitor II ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
• Description: Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
• Uses: Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).