4,6-Dichloro-2-cyclopropylpyrimidine

Base Information

• Chemical Name: 4,6-Dichloro-2-cyclopropylpyrimidine
• CAS No.: 7043-09-6
• Molecular Formula: C7H6Cl2N2
• Molecular Weight: 189.0419
• Hs Code.: 2933599090
• Mol file: 7043-09-6.mol

Synonyms:4,6-Dichloro-2-cyclopropyl-pyrimidine;

Chemical Property of 4,6-Dichloro-2-cyclopropylpyrimidine

Chemical Property:

• Melting Point: 105-107 °C
• Boiling Point: 268.5 °C at 760 mmHg
• PKA: -3.63±0.30(Predicted)
• Flash Point: 142.1 °C
• PSA: 25.78000
• Density: 1.479 g/cm³
• LogP: 2.66080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dichloro-2-cyclopropylpyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-Dichloro-2-cyclopropylpyrimidine

There total 2 articles about 4,6-Dichloro-2-cyclopropylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-cyclopropyl-4,6-dihydroxy-pyrimidine (7024-58-0) → 4,6-dichloro-2-cyclopropylpyrimidine (7043-09-6)

Guidance literature:

2-cyclopropyl-4,6-dihydroxy-pyrimidine; With trichlorophosphate; for 2h; Reflux;

With sodium hydroxide; In water; Cooling with ice;

Reference yield:

→ 4,6-dichloro-2-cyclopropylpyrimidine (7043-09-6)

Guidance literature:

upstream raw materials:

2-cyclopropyl-4,6-dihydroxy-pyrimidine

Refernces

• 1、 -. "Novel Compounds". Page/Page column 68. . Retrieved 2012/04/18.
• 2、 Provins, Laurent,Christophe, Bernard,Danhaive, Pierre,Dulieu, Jacques,Durieu, Véronique,Gillard, Michel,Lebon, Florence,Lengelé, Sébastien,Quéré, Luc,Van Keulen, Berendjan. "First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives". . p. 1834 - 1839. Retrieved 2007/10/03.