dimethyl phosphonate

Base Information

• Chemical Name: dimethyl phosphonate
• CAS No.: 132205-80-2
• Molecular Formula: C₁₀H₁₅O₄P
• Molecular Weight: 230.2
• Mol file: 132205-80-2.mol

Synonyms:

Chemical Property of dimethyl phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl phosphonate

There total 17 articles about dimethyl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

benzaldehyde dimethyl acetal (1125-88-8) + phosphorous acid trimethyl ester (121-45-9) → dimethyl phosphonate (132205-80-2,62456-45-5)

Guidance literature:

With zinc(II) chloride; In dichloromethane; 1.) -24 deg C slowly -> room temperature, 2.) 72 h;

DOI:10.1021/jo00006a052

Reference yield: 85.0%

benzaldehyde dimethyl acetal (1125-88-8) + methyl hypophosphorous acid methyl ester (16391-06-3) → dimethyl phosphonate (132205-80-2,62456-45-5)

Guidance literature:

boron trifluoride diethyl etherate; at 150 - 170 ℃; for 1.5h;

Reference yield: 66.0%

dimethyl 1-hydroxy-1-phenylmethylphosphonate (6329-46-0,79296-54-1,97995-93-2,147731-04-2) + methyl iodide (74-88-4) → dimethyl phosphonate (132205-80-2,62456-45-5)

Guidance literature:

With acetic acid; silver(l) oxide; for 22h; Darkness;

DOI:10.1002/adsc.201100459

upstream raw materials:

α-chlorobenzyl methyl ether

phosphorous acid trimethyl ester

diazomethane

α-methoxybenzylphosphonic acid

Downstream raw materials:

trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene

tert-butyl 2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

(+/-)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate

(+/-)-methyl p-nitrophenyl [1-(methoxy)phenylmethyl]phosphonate

Refernces

• 1、 Zhu, Shou-Fei,Chen, Wang-Qiao,Zhang, Qian-Qian,Mao, Hong-Xiang,Zhou, Qi-Lin. "Enantioselective copper-catalyzed O-H insertion of α-diazo phosphonates". scheme or table. p. 919 - 922. Retrieved 2011/06/17.
• 2、 Roeschlaub, Carl A.,Sammes, Peter G.. "Use of the Wadsworth-Emmons reaction for preparing hindered vinyl ethers and related 1,2-dioxetanes". . p. 2243 - 2248. Retrieved 2007/10/03.