Technology Process of (E)-3-[(1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-propenal
There total 7 articles about (E)-3-[(1R,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-propenal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) m-chloroperoxybenzoic acid, 2.) triethylamine / 1.) 0 degC, 4h, CCl4; 2.) 55 degC, 3h
2: 100 percent / 4-dimethylaminopyridine / CH2Cl2 / 21 h / Heating
3: 98 percent / sodium bicarbonate / 3 h / 23 °C
4: 94 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 / 64 h / 23 °C
5: diisobutylaluminiumhydride / hexane / 0.5 h / -78 °C
6: 1.) Li; 2.) trifluoracetic acid / 1.) THF, -20 degC, 1.5 h; 2.) THF, 0 degC, 1 h
With
dmap; 2,6-di-tert-butyl-4-methylpyridine; lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
hexane; dichloromethane;
DOI:10.1016/S0040-4039(01)93750-5
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / 4-dimethylaminopyridine / CH2Cl2 / 21 h / Heating
2: 98 percent / sodium bicarbonate / 3 h / 23 °C
3: 94 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 / 64 h / 23 °C
4: diisobutylaluminiumhydride / hexane / 0.5 h / -78 °C
5: 1.) Li; 2.) trifluoracetic acid / 1.) THF, -20 degC, 1.5 h; 2.) THF, 0 degC, 1 h
With
dmap; 2,6-di-tert-butyl-4-methylpyridine; lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; trifluoroacetic acid;
In
hexane; dichloromethane;
DOI:10.1016/S0040-4039(01)93750-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / sodium bicarbonate / 3 h / 23 °C
2: 94 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 / 64 h / 23 °C
3: diisobutylaluminiumhydride / hexane / 0.5 h / -78 °C
4: 1.) Li; 2.) trifluoracetic acid / 1.) THF, -20 degC, 1.5 h; 2.) THF, 0 degC, 1 h
With
2,6-di-tert-butyl-4-methylpyridine; lithium; diisobutylaluminium hydride; sodium hydrogencarbonate; trifluoroacetic acid;
In
hexane; dichloromethane;
DOI:10.1016/S0040-4039(01)93750-5