6-Bromo-3-chloro-imidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 6-Bromo-3-chloro-imidazo[1,2-a]pyrazine
• CAS No.: 1239441-36-1
• Molecular Formula: C₆H₃BrClN₃
• Molecular Weight: 232.467
• Mol file: 1239441-36-1.mol

Synonyms:

Chemical Property of 6-Bromo-3-chloro-imidazo[1,2-a]pyrazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-3-chloro-imidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromo-3-chloro-imidazo[1,2-a]pyrazine

There total 1 articles about 6-Bromo-3-chloro-imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-bromo-imidazo[1,2-a]pyrazine (912773-24-1) → 3-chloro-6-bromoimidazo[1,2-a]pyrazine (1239441-36-1)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; for 5.5h; Reflux;

DOI:10.1016/j.bmcl.2010.05.096

Reference yield:

3-chloro-6-bromoimidazo[1,2-a]pyrazine (1239441-36-1) + p-hydroxymethylphenylboronic acid (59016-93-2) → C13H10ClN3O (1239441-63-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 120 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.05.096

Reference yield:

3-chloro-6-bromoimidazo[1,2-a]pyrazine (1239441-36-1) + 3-Aminophenylboronic acid (30418-59-8,280563-63-5) → C12H9ClN4 (1239441-59-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 120 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.05.096

upstream raw materials:

6-bromo-imidazo[1,2-a]pyrazine

Downstream raw materials:

C₁₃H₁₀ClN₃O

C₁₂H₉ClN₄

C₁₃H₁₁ClN₄

C₁₂H₉ClN₄

Refernces

• 1、 Matthews, Thomas P.,McHardy, Tatiana,Klair, Suki,Boxall, Kathy,Fisher, Martin,Cherry, Michael,Allen, Charlotte E.,Addison, Glynn J.,Ellard, John,Aherne, G. Wynne,Westwood, Isaac M.,Montfort, Rob van,Garrett, Michelle D.,Reader, John C.,Collins, Ian. "Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases". scheme or table. p. 4045 - 4049. Retrieved 2010/08/19.