(R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane

Base Information

• Chemical Name: (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane
• CAS No.: 1575839-52-9
• Molecular Formula: C₃₁H₃₂OSi
• Molecular Weight: 448.68
• Mol file: 1575839-52-9.mol

Synonyms:

Chemical Property of (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane

There total 9 articles about (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-Tetrahydro-1-naphthol (529-33-9) → (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane (1575839-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

1.2: 24 h / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

2.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

2.2: -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

With Levamisole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jo402569h

Reference yield:

tris(4-bromophenyl)((1,2,3,4-tetrahydronaphthalen-1-yl)-oxy)silane → (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane (1575839-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

2.2: 24 h / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

3.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

3.2: -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

With tetrabutyl ammonium fluoride; Levamisole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jo402569h

Reference yield:

triphenyl((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)silane → (R)-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)tri-p-tolylsilane (1575839-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

2.2: 24 h / -78 °C / Inert atmosphere; Molecular sieve; Resolution of racemate

3.1: Levamisole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

3.2: -78 °C / Inert atmosphere; Schlenk technique; Molecular sieve

With tetrabutyl ammonium fluoride; Levamisole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jo402569h

upstream raw materials:

chlorotris(p-methylphenyl)silane

(R)-1-tetralol

1,2,3,4-Tetrahydro-1-naphthol

Refernces