5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole

Base Information

• Chemical Name: 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole
• CAS No.: 1337952-50-7
• Molecular Formula: C₂₅H₂₅NO₂
• Molecular Weight: 371.479
• Mol file: 1337952-50-7.mol

Synonyms:

Chemical Property of 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole

There total 5 articles about 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-Bromopentane (110-53-2) + (5-methoxy-1H-indol-3-yl)(naphthalen-1-yl)methanone (1226361-43-8) → 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole (1337952-50-7)

Guidance literature:

(5-methoxy-1H-indol-3-yl)(naphthalen-1-yl)methanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 40 ℃; for 1h; Inert atmosphere;

1-Bromopentane; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃; for 1h;

Reference yield:

1-Bromopentane (110-53-2) + (5-methoxy-1H-indol-3-yl)(naphthalen-1-yl)methanone (1226361-43-8) + [1-(5-fluoropentyl)-1H-indole-3-yl](naphthalene-1-yl)methanone (335161-24-5) → 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole (1337952-50-7)

Guidance literature:

With sodium hydride; In hexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

5-methoxylindole (1006-94-6) → 5-methoxy-3-(1-naphthoyl)-N-pentyl-1H-indole (1337952-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; methylmagnesium bromide / diethyl ether

2: sodium hydride / ethyl acetate; N,N-dimethyl-formamide; hexane; water; mineral oil

With sodium hydride; methylmagnesium bromide; ammonium chloride; In diethyl ether; hexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

1-Bromopentane

(5-methoxy-1H-indol-3-yl)(naphthalen-1-yl)methanone

[1-(5-fluoropentyl)-1H-indole-3-yl](naphthalene-1-yl)methanone

5-methoxylindole

Downstream raw materials:

(5-hydroxy-1-pentyl-1H-indol-3-yl)(naphthalen-1-yl)methanone

Refernces

• 1、 -. "Detection of Synthetic Cannabinoids". . . Retrieved 2012/08/28.