3-iodo-cocaine

Base Information

• Chemical Name: 3-iodo-cocaine
• CAS No.: 141120-38-9
• Molecular Formula: C₁₇H₂₀INO₄
• Molecular Weight: 429.255
• Mol file: 141120-38-9.mol

Synonyms:

Chemical Property of 3-iodo-cocaine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-iodo-cocaine

There total 2 articles about 3-iodo-cocaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Iodobenzoic acid (618-51-9) → 3-iodo-cocaine (141120-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 25 h / Heating

2: 1.) NaH / 1.) THF, 10 min, 2.) THF, reflux

With thionyl chloride; sodium hydride;

DOI:10.1021/jm00090a005

Reference yield:

3-iodobenzoyl chloride (1711-10-0) + methyl ecgonine (7143-09-1) → 3-iodo-cocaine (141120-38-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 10 min, 2.) THF, reflux;

DOI:10.1021/jm00090a005

Reference yield:

3-iodo-cocaine (141120-38-9) → 3-<(3-iodobenzoyl)oxy>-<1R-(exo,exo)>-8-azabicyclo<3.2.1.>octane-2-carboxylic acid methyl ester (141170-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-bis-(dimethylamino)naphthalene / 1,2-dichloro-ethane / 1.5 h / Heating

2: MeOH / 1 h / Heating

With methanol; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In 1,2-dichloro-ethane;

DOI:10.1021/jm00090a005

upstream raw materials:

3-iodobenzoyl chloride

methyl ecgonine

3-Iodobenzoic acid

Downstream raw materials:

3-<(3-iodobenzoyl)oxy>-<1R-(exo,exo)>-8-azabicyclo<3.2.1.>octane-2-carboxylic acid methyl ester

Refernces