N,N'-Desethylene Levofloxacin Hydrochloride

Base Information

• Chemical Name: N,N'-Desethylene Levofloxacin Hydrochloride
• CAS No.: 151250-76-9
• Molecular Formula: C₁₆H₁₈FN₃O₄
• Molecular Weight: 335.335
• Mol file: 151250-76-9.mol

Synonyms:

Chemical Property of N,N'-Desethylene Levofloxacin Hydrochloride

Chemical Property:

• Melting Point: 264-266°C
• Boiling Point: 561.8±50.0 °C(Predicted)
• PKA: 5.33±0.40(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,N''-Desethylene Levofloxacin is an impurity of Levofloxacin (L360255). Levofloxacin is an antibiotic. Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution.

Technology Process of N,N'-Desethylene Levofloxacin Hydrochloride

There total 4 articles about N,N'-Desethylene Levofloxacin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

N-methyl-(2-aminoethyl)amine hydrochloride + levofloxacin Q-acid (100986-89-8) → S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1,4-diazapentyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid (151250-76-9)

Guidance literature:

N-methyl-(2-aminoethyl)amine hydrochloride; With triethylamine; In dimethyl sulfoxide; for 1.5h;

levofloxacin Q-acid; In dimethyl sulfoxide; at 50 - 60 ℃; for 1.5h; Concentration;

Reference yield:

levofloxacin (100986-85-4,83380-47-6) → carbon dioxide (124-38-9,18923-20-1) + C13H12N2O4 + C9H8N2O2 + C16H18FN3O4 (151250-76-9) + C14H11FN2O5 + C16H19N3O4 + fluoride (16984-48-8) + Nitrate (14797-55-8) + acetic acid (64-19-7,77671-22-8) + 1-(3-hydroxyphenyl)prop-2-en-1-one (95605-37-1) + 10-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (86794-33-4) + citric acid (77-92-9,906507-37-7) + 9-fluoro-2,3-dihydro-3-methyl-10-(N-methyl-N',N-diformyl-2-aminoethylamino)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (151377-74-1)

Guidance literature:

With water; for 0.166667h; Reagent/catalyst; Time; Mechanism; Photolysis;

DOI:10.1039/c8cy02073f

Reference yield:

levofloxacin (100986-85-4,83380-47-6) → S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-amino-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid + S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1,4-diazapentyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid (151250-76-9) + S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1-piperazinyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid (117707-40-1) + S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-formyl-1,4-diazapentyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid + S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1-formyl-1,4-diazapentyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid + S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1,4-diformyl-1,4-diazapentyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid (151377-74-1)

Guidance literature:

In water; for 16h; Product distribution; Ambient temperature; Irradiation; investigation of the photodegradation;

upstream raw materials:

levofloxacin

levofloxacin Q-acid

Levofloxacin hydrochloride

Refernces

• 1、 Yang, Yuxin,Hu, An,Wang, Xinyue,Meng, Jiaqi,Guo, Yihang,Huo, Mingxin,Zhu, Suiyi. "Nanopore enriched hollow carbon nitride nanospheres with extremely high visible-light photocatalytic activity in the degradation of aqueous contaminants of emerging concern". . p. 355 - 365. Retrieved 2019/01/28.
• 2、 Yoshida,Sato,Moroi. "Photodegradation products of levofloxacin in aqueous solution". . p. 601 - 606. Retrieved 2007/10/02.