Technology Process of methyl-1 <α-(methoxy-4' formyl-3' phenyl)-1' ethyl>-2 chloro-4 pyrrolo<3,2-c>pyridine
There total 9 articles about methyl-1 <α-(methoxy-4' formyl-3' phenyl)-1' ethyl>-2 chloro-4 pyrrolo<3,2-c>pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 60.7 percent / tert-butyllithium / tetrahydrofuran / 1.) -65 deg C, 30 min, 2.) room temp., 1 h
2: 89 percent / p-toluenesulfonic acid / xylene / 24 h / Heating
3: 85 percent / H2 / 10percent Pd/C / acetic acid / 0.75 h / Ambient temperature; at normal pressure
4: 50 percent / POCl3 / 3 h / Heating
5: SnCl4 / 1,2-dichloro-ethane / 1.) 0 deg C, 1 h, 2.) reflux, 3 h
With
hydrogen; tert.-butyl lithium; tin(IV) chloride; toluene-4-sulfonic acid; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; 1,2-dichloro-ethane; xylene;
DOI:10.1139/v86-087
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / tert-butyllithium / tetrahydrofuran / 1.) -65 deg C, 45 min, 2.) room temp., 1 h
2: 26.4 percent / acetic anhydride / 18 h / Heating
3: 85 percent / H2 / 10percent Pd/C / acetic acid / 0.75 h / Ambient temperature; at normal pressure
4: 50 percent / POCl3 / 3 h / Heating
5: SnCl4 / 1,2-dichloro-ethane / 1.) 0 deg C, 1 h, 2.) reflux, 3 h
With
hydrogen; tert.-butyl lithium; tin(IV) chloride; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; acetic anhydride; acetic acid; 1,2-dichloro-ethane;
DOI:10.1139/v86-087
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 60.7 percent / tert-butyllithium / tetrahydrofuran / 1.) -65 deg C, 30 min, 2.) room temp., 1 h
2: 89 percent / p-toluenesulfonic acid / xylene / 24 h / Heating
3: 85 percent / H2 / 10percent Pd/C / acetic acid / 0.75 h / Ambient temperature; at normal pressure
4: 50 percent / POCl3 / 3 h / Heating
5: SnCl4 / 1,2-dichloro-ethane / 1.) 0 deg C, 1 h, 2.) reflux, 3 h
With
hydrogen; tert.-butyl lithium; tin(IV) chloride; toluene-4-sulfonic acid; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; 1,2-dichloro-ethane; xylene;
DOI:10.1139/v86-087