3β-Glycocholic Acid

Base Information

• Chemical Name: 3β-Glycocholic Acid
• CAS No.: 107589-98-0
• Molecular Formula: C₂₆H₄₃NO₆
• Molecular Weight: 465.631
• Mol file: 107589-98-0.mol

Synonyms:

Chemical Property of 3β-Glycocholic Acid

Chemical Property:

• Melting Point: 151-154°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3β-GlycocholicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cholenoic acid present in significant proportions during early gastation.

Technology Process of 3β-Glycocholic Acid

There total 4 articles about 3β-Glycocholic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ <3α,7α,12α-Trihydroxy-5β-cholanoyl-(24)-amino>-essigsaeure, N-<3α,7α,12α-Trihydroxy-5β-cholanoyl-(24)>-glycin, Glykocholsaeure (475-31-0,66421-55-4,68753-47-9,68753-50-4,68753-51-5,107589-98-0,139777-83-6)

Guidance literature:

Glycocholsaeurebenzylester, H2, Palladiumoxyd, Me.;

Reference yield:

→ Glycocholsaeure (475-31-0,66421-55-4,68753-47-9,68753-50-4,68753-51-5,107589-98-0,139777-83-6)

Guidance literature:

Cholsaeure, 1) H2NCH2COOEt*HCl, /BRN= 533048/, NEt3, 2) 10percent K2CO3, 3) HCl;

Reference yield:

[(R)-4-((5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-acetic acid (88725-38-6) → glycocholic acid (107589-98-0)

Guidance literature:

With 1,4-dihydronicotinamide adenine dinucleotide; DL-dithiothreitol; In ethanol; water; for 30h; 3β-hydroxysteroid dehydrogenase, formate/formate dehydrogenase, potassium phosphate buffer pH=7.2;

DOI:10.1021/jo00236a018

upstream raw materials:

[(R)-4-((5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-acetic acid

sodium glycocholate

Refernces

• 1、 Tserng,Hachey,Klein. "An improved procedure for the synthesis of glycine and taurine conjugates of bile acids". . p. 404 - 407. Retrieved 2007/10/06.