S-trityl-2-mercaptopropionic acid

Base Information

• Chemical Name: S-trityl-2-mercaptopropionic acid
• CAS No.: 75286-49-6
• Molecular Formula: C₂₂H₂₀O₂S
• Molecular Weight: 348.466
• Mol file: 75286-49-6.mol

Synonyms:

Chemical Property of S-trityl-2-mercaptopropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-trityl-2-mercaptopropionic acid

There total 4 articles about S-trityl-2-mercaptopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

PE + triphenylmethanethiol (3695-77-0) + 2-Bromopropionic acid (598-72-1,10327-08-9) → S-trityl-2-mercaptopropionic acid (75286-49-6,75368-95-5)

Guidance literature:

With potassium hydrogensulfate; NaH; In chloroform; N,N-dimethyl-formamide; mineral oil;

Reference yield: 75.0%

triphenylmethyl alcohol (76-84-6) + 2-mercaptopropanoic acid (79-42-5) → S-trityl-2-mercaptopropionic acid (75286-49-6,75368-95-5)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 3h;

DOI:10.1002/cmdc.201100522

Reference yield: 65.0%

trityl chloride (76-83-5) + 2-mercaptopropanoic acid (79-42-5) → S-trityl-2-mercaptopropionic acid (75286-49-6,75368-95-5)

Guidance literature:

In N,N-dimethyl-formamide; for 48h; Ambient temperature;

upstream raw materials:

trityl chloride

2-mercaptopropanoic acid

triphenylmethanethiol

2-Bromopropionic acid

Downstream raw materials:

N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

N-[7-(3-methyl-5-phenylisoxazol-4-yl)hept-6-ynyl]-2-tritylsulfanylpropionamide

5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

(R)-5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

Refernces

• 1、 Chen, Fener,De Clercq, Erik,Pannecouque, Christophe,Sang, Yali,Zhuang, Chunlin. "Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase". . . Retrieved 2020/02/03.
• 2、 Kalin, Jay H.,Zhang, Hankun,Gaudrel-Grosay, Sophie,Vistoli, Giulio,Kozikowski, Alan P.. "Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress". experimental part. p. 425 - 439. Retrieved 2012/06/04.