Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride

Base Information

• Chemical Name: Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride
• CAS No.: 101089-40-1
• Molecular Formula: C15H15NO.ClH
• Molecular Weight: 261.751
• DSSTox Substance ID: DTXSID30467642
• Mol file: 101089-40-1.mol

Synonyms:101089-40-1;Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride;SCHEMBL10339600;DTXSID30467642;N-benzylphenacylamine hydrochloride

Chemical Property of Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 261.0920418
• Heavy Atom Count: 18
• Complexity: 227

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNCC(=O)C2=CC=CC=C2.Cl

Technology Process of Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride

There total 1 articles about Ethanone, 1-phenyl-2-[(phenylmethyl)amino]-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-bromoacetophenone (70-11-1) + benzylamine (100-46-9) → 2-(benzylamino)-1-phenylethanone hydrochloride (101089-40-1)

Guidance literature:

α-bromoacetophenone; benzylamine; In diethyl ether; at 0 ℃; for 16.1667h;

With hydrogenchloride; In diethyl ether; water; at 0 ℃;

DOI:10.1016/j.tet.2009.03.103

Reference yield: 100.0%

2-(benzylamino)-1-phenylethanone hydrochloride (101089-40-1) → (S)-(+)-2-(N-Benzylamino)-1-phenylethanol (51096-49-2)

Guidance literature:

With hydrogen; triethylamine; (2S,4S)-MCCPM-rhodium; In methanol; at 50 ℃; for 20h; under 15200 Torr;

DOI:10.1016/S0040-4039(00)95203-1

Reference yield: 90.0%

4-(6-chloro-5-nitropyrimidin-4-yl)morpholine (54660-14-9) + 2-(benzylamino)-1-phenylethanone hydrochloride (101089-40-1) → 9-benzyl-6-morpholinopurin-8-one

Guidance literature:

With triethylamine; In methanol; for 0.25h; Heating;

DOI:10.1007/s10593-005-0256-7

upstream raw materials:

α-bromoacetophenone

benzylamine

Downstream raw materials:

(S)-(+)-2-(N-Benzylamino)-1-phenylethanol

2-amino-6--5-nitro-4(3H)-pyrimidinone

9-benzylguanine 7-oxide

1-benzyl-4-phenyl-1,3-dihydro-imidazole-2-thione

Refernces