C₂₈H₂₆F₉N₉O

Base Information

• Chemical Name: C₂₈H₂₆F₉N₉O
• CAS No.: 1374437-12-3
• Molecular Formula: C₂₈H₂₆F₉N₉O
• Molecular Weight: 675.56
• Mol file: 1374437-12-3.mol

Synonyms:

Chemical Property of C₂₈H₂₆F₉N₉O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₆F₉N₉O

There total 11 articles about C₂₈H₂₆F₉N₉O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethyl-2H-pyrazole-3-carbonyl chloride (160886-90-8) + C22H20F9N7 (867012-72-4) → C28H26F9N9O (1374437-12-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

C13H16F3N3O → C28H26F9N9O (1374437-12-3)

Guidance literature:

Multi-step reaction with 9 steps

1: pyridine / 0 - 20 °C

2: hydrogenchloride / water / 80 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: sodium azide; triethylamine / toluene / 110 °C

6: potassium carbonate / acetonitrile

7: Chiralpak AD / Resolution of racemate

8: sulfuric acid; trifluoroacetic acid / 0 - 20 °C

9: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; sodium azide; sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

C17H22F3N3O3 → C28H26F9N9O (1374437-12-3)

Guidance literature:

Multi-step reaction with 8 steps

1: hydrogenchloride / water / 80 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: sodium azide; triethylamine / toluene / 110 °C

5: potassium carbonate / acetonitrile

6: Chiralpak AD / Resolution of racemate

7: sulfuric acid; trifluoroacetic acid / 0 - 20 °C

8: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; sodium azide; sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.03.075

upstream raw materials:

2,4-dimethyl-2H-pyrazole-3-carbonyl chloride

C₂₂H₂₀F₉N₇

(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

6-(trifluoromethyl)pyridin-3-amine

Refernces