3-nitro-4-methyl-trans-cinnamic acid

Base Information

• Chemical Name: 3-nitro-4-methyl-trans-cinnamic acid
• CAS No.: 127791-55-3
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.186
• Mol file: 127791-55-3.mol

Synonyms:

Chemical Property of 3-nitro-4-methyl-trans-cinnamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-nitro-4-methyl-trans-cinnamic acid

There total 3 articles about 3-nitro-4-methyl-trans-cinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 3-nitro-4-methyl-trans-cinnamic acid (127791-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated sulfuric acid; concentrated nitric acid / 0 - 3 °C

2: pyridine; piperidine

With piperidine; pyridine; sulfuric acid; nitric acid;

DOI:10.1021/ja01301a066

Reference yield:

4-methyl-3-nitrobenzaldehyde (31680-07-6) + malonic acid (141-82-2) → 3-nitro-4-methyl-trans-cinnamic acid (127791-55-3)

Guidance literature:

With piperidine; pyridine;

DOI:10.1021/ja01301a066

Reference yield:

4-Methyl-3-nitroanilin (119-32-4) → 3-nitro-4-methyl-trans-cinnamic acid (127791-55-3)

Guidance literature:

Diazotization_.Eintragen in ein Gemisch von Maleinsaeure, Natriumacetat, Kupfer(II)-chlorid und Wasser bei 30-40grad;

DOI:10.1007/BF02803192

upstream raw materials:

4-methyl-3-nitrobenzaldehyde

malonic acid

4-Methyl-3-nitroanilin

4-methyl-benzaldehyde

Downstream raw materials:

3-(3-hydroxy-4-methyl-phenyl)-propionic acid

3-(3-methoxy-4-methylphenyl)propanoic acid

3-(3-amino-4-methyl-phenyl)-propionic acid