Naphthalene, 2-ethyl-1-phenyl-

Base Information

• Chemical Name: Naphthalene, 2-ethyl-1-phenyl-
• CAS No.: 101735-32-4
• Molecular Formula: C18H16
• Molecular Weight: 232.325
• Mol file: 101735-32-4.mol

Synonyms:

Chemical Property of Naphthalene, 2-ethyl-1-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Naphthalene, 2-ethyl-1-phenyl-

There total 11 articles about Naphthalene, 2-ethyl-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)-3-ethyl-4-phenyl-1,2-dihydronaphthalene → 1-phenyl-2-ethylnaphthalene (101735-32-4)

Guidance literature:

With gallium(III) trichloride; In dichloromethane; at 40 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00209

Reference yield: 97.0%

styrene oxide (96-09-3) + 1-phenyl-1-butyne (622-76-4,83585-27-7) → 1-phenyl-2-ethylnaphthalene (101735-32-4)

Guidance literature:

With p-toluenesulfonyl chloride; methyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 110 ℃; for 16h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1016/j.cclet.2021.12.012

Reference yield: 73.0%

1-phenyl-1-butyne (622-76-4,83585-27-7) + phenylacetaldehyde (122-78-1) → 1-phenyl-2-ethylnaphthalene (101735-32-4)

Guidance literature:

With iron(III) chloride; In 1,2-dichloro-ethane; at 18 - 26 ℃; for 2h; regioselective reaction;

DOI:10.1016/j.tet.2012.07.007

upstream raw materials:

2-Aethyl-1-phenyl-3,4-dihydro-naphthalin

1-phenyl-1-butyne

phenylacetaldehyde

styrene oxide

Refernces

• 1、 Novikov, Roman A.,Tarasova, Anna V.,Denisov, Dmitry A.,Borisov, Denis D.,Korolev, Victor A.,Timofeev, Vladimir P.,Tomilov, Yury V.. "[4 + 2] Annulation of Donor-Acceptor Cyclopropanes with Acetylenes Using 1,2-Zwitterionic Reactivity". . p. 2724 - 2738. Retrieved 2017.
• 2、 Umeda, Rui,Nishi, Satoru,Kojima, Aya,Kaiba, Kenta,Nishiyama, Yutaka. "Rhenium-catalyzed regioselective synthesis of 1,2-disubstituted naphthalenes". supporting information. p. 179 - 182. Retrieved 2013/02/21.