3'-Chloro-3-hydroxy-2-methoxyflavanone

Base Information

• Chemical Name: 3'-Chloro-3-hydroxy-2-methoxyflavanone
• CAS No.: 136764-63-1
• Molecular Formula: C₁₆H₁₃ClO₄
• Molecular Weight: 304.73
• Mol file: 136764-63-1.mol

Synonyms:

Chemical Property of 3'-Chloro-3-hydroxy-2-methoxyflavanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Chloro-3-hydroxy-2-methoxyflavanone

There total 3 articles about 3'-Chloro-3-hydroxy-2-methoxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-Chloroflavone (1849-61-2) → 3'-Chloro-3-hydroxy-2-methoxyflavanone (136764-63-1,136764-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / dimethyldioxirane / acetone; CH₂Cl₂ / 28 h / 20 °C

2: 24 h / 20 °C

With 3,3-dimethyldioxirane; In dichloromethane; acetone;

DOI:10.1021/jo00026a020

Reference yield:

1-(3-Chloro-phenyl)-3-(2-hydroxy-phenyl)-propane-1,3-dione (5067-21-0) → 3'-Chloro-3-hydroxy-2-methoxyflavanone (136764-63-1,136764-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid, glacial acetic acid

2: 100 percent / dimethyldioxirane / acetone; CH₂Cl₂ / 28 h / 20 °C

3: 24 h / 20 °C

With sulfuric acid; 3,3-dimethyldioxirane; acetic acid; In dichloromethane; acetone;

DOI:10.1021/jo00026a020

Reference yield:

methanol (67-56-1) + 1a,7a-Dihydro-1a-(3-chlorophenyl)-7H-oxireno<1>benzopyran-7-one (134051-35-7) → 3'-Chloro-3-hydroxy-2-methoxyflavanone (136764-63-1,136764-64-2)

Guidance literature:

at 20 ℃; for 24h; Yield given;

DOI:10.1021/jo00026a020

upstream raw materials:

methanol

1a,7a-Dihydro-1a-(3-chlorophenyl)-7H-oxireno<1>benzopyran-7-one

3'-Chloroflavone

1-(3-Chloro-phenyl)-3-(2-hydroxy-phenyl)-propane-1,3-dione

Refernces