3-Amino-3-methyl-2-butanone hydrochloride

Base Information

• Chemical Name: 3-Amino-3-methyl-2-butanone hydrochloride
• CAS No.: 10201-15-7
• Molecular Formula: C5H11NO.ClH
• Molecular Weight: 137.609
• European Community (EC) Number: 871-680-1
• DSSTox Substance ID: DTXSID90496418
• Mol file: 10201-15-7.mol

Synonyms:10201-15-7;3-Amino-3-methyl-2-butanone hydrochloride;3-Amino-3-methylbutan-2-one hydrochloride;3-amino-3-methylbutan-2-one;hydrochloride;3-Amino-3-methyl-2-butanone HCl;2-Butanone, 3-amino-3-methyl-, hydrochloride (1:1);DTXSID90496418;3-Amino-3-methylbutan-2-one HCl;MFCD09028983;AKOS024397352;SB75670;3-Amino-3-methylbutan-2-onehydrochloride;AM806454;AS-68434;(2-Methyl-3-oxobutan-2-yl)azanium;chloride;CS-0036060;EN300-192383;3-Amino-3-methylbutan-2-one--hydrogen chloride (1/1)

Chemical Property of 3-Amino-3-methyl-2-butanone hydrochloride

Chemical Property:

• PSA: 43.09000
• LogP: 1.81500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.0607417
• Heavy Atom Count: 8
• Complexity: 86.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-3-methyl-2-butanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C(C)(C)N.Cl

Technology Process of 3-Amino-3-methyl-2-butanone hydrochloride

There total 8 articles about 3-Amino-3-methyl-2-butanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.3%

2,3,3,5,6,6-hexamethyl-3,6-dihydropyrazine hexahydrate (36848-44-9) → 3-amino-3-methyl-2-butanone hydrochloride (10201-15-7)

Guidance literature:

With hydrogenchloride; for 72h; Heating;

DOI:10.1021/jo00181a013

Reference yield: 52.0%

2,3,3,5,6,6-hexamethyl-3,6-dihydropyrazine (36848-44-9) → 3-amino-3-methyl-2-butanone hydrochloride (10201-15-7)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1016/S0040-4039(00)96478-5

Reference yield:

3-benzamido-3-methylbutan-2-one (37557-72-5) → 3-amino-3-methyl-2-butanone hydrochloride (10201-15-7) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; for 8h; Yield given; Heating;

upstream raw materials:

2,3,3,5,6,6-hexamethyl-3,6-dihydropyrazine

3-benzamido-3-methylbutan-2-one

2,3,3,5,6,6-hexamethyl-3,6-dihydropyrazine hexahydrate

3-azido-3-methylbutan-2-one

Refernces

• 1、 Al-Hassan, Saiba S.,Cameron, Robert J.,Curran, Adrian W. C.,Lyall, William J. S.,Nicholson, Sydney H.,et al.. "Specific Inhibitors in Vitamin Biosynthesis. Part 7. Syntheses of Blocked 7,8-Dihydropteridines via &α-Amino Ketones". . p. 1645 - 1660. Retrieved 2007/10/02.
• 2、 -. "Method of synthesis of pteridines". . . Retrieved 2008/06/13.