6β-naltrexol

Base Information

• Chemical Name: 6β-naltrexol
• CAS No.: 100678-48-6
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423
• Mol file: 100678-48-6.mol

Synonyms:

Chemical Property of 6β-naltrexol

Chemical Property:

Purity/Quality:

Naltrexol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Naltrexol is a metabolite of Naltrexone. Narcotic antagonist.

Technology Process of 6β-naltrexol

There total 9 articles about 6β-naltrexol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Naltrexone (16590-41-3) + phenethylamine (64-04-0) → 6β-naltrexol (100678-48-6) + C28H34N2O3

Guidance literature:

Naltrexone; With triphenylphosphine; Wang resin; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 19h;

phenethylamine; With sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide; for 28h;

With trifluoroacetic acid; In dichloromethane;

Reference yield:

Naltrexone (16590-41-3) + aniline (62-53-3) → 6β-naltrexol (100678-48-6) + C26H30N2O3

Guidance literature:

Naltrexone; With triphenylphosphine; Wang resin; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 19h;

aniline; With sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide; for 28h;

With trifluoroacetic acid; In dichloromethane;

Reference yield:

Naltrexone (16590-41-3) + benzylamine (100-46-9) → 6β-naltrexol (100678-48-6) + C27H32N2O3

Guidance literature:

Naltrexone; With triphenylphosphine; Wang resin; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 19h;

benzylamine; With sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide; for 28h;

With trifluoroacetic acid; In dichloromethane;

upstream raw materials:

Naltrexone

methylamine hydrochloride

ethylamine

phenethylamine

Downstream raw materials:

C₂₂H₂₆FNO₄

Refernces

• 1、 Banks, Stan L.,Pinninti, Raghotham R.,Gill, Harvinder S.,Paudel, Kalpana S.,Crooks, Peter A.,Brogden, Nicole K.,Prausnitz, Mark R.,Stinchcomb, Audra L.. "Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs". experimental part. p. 3072 - 3080. Retrieved 2011/04/22.
• 2、 Ohno, Hiroshi,Kawamura, Kuniaki,Otake, Atsushi,Nagase, Hiroshi,Tanaka, Hiroshi,Takahashi, Takashi. "Solid-Phase Synthesis of 6-Sulfonylamino Morphinan Libraries". . p. 92 - 96. Retrieved 2007/10/03.