threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol

Base Information

• Chemical Name: threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol
• CAS No.: 117841-12-0
• Molecular Formula: C₁₅H₁₅ClO₃S
• Molecular Weight: 310.801
• Mol file: 117841-12-0.mol

Synonyms:

Chemical Property of threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol

There total 14 articles about threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-phenylpropan-1-one (6084-17-9) → erythro-2-chloro-1-phenyl-2-phenylsulfonylpropanol (117841-12-0,117841-27-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / 1.9 M NaOH / n-Bu₄NBr / CH₂Cl₂ / 12 h

2: 82 percent / 30percent H₂O₂ / ammonium molybdate / methanol

3: 1.) NaH, 2.) NCS / 1.) toluene, 2.) toluene

4: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; dihydrogen peroxide; sodium hydride; ammonium molybdate; tetrabutylammomium bromide; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

2-chloro-1-phenylpropan-1-one (6084-17-9) → threo-2-chloro-1-phenyl-2-phenylsulfonylpropanol (117841-12-0,117841-27-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / 1.9 M NaOH / n-Bu₄NBr / CH₂Cl₂ / 12 h

2: 82 percent / 30percent H₂O₂ / ammonium molybdate / methanol

3: 1.) NaH, 2.) NCS / 1.) toluene, 2.) toluene

4: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; dihydrogen peroxide; sodium hydride; ammonium molybdate; tetrabutylammomium bromide; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

1-phenyl-2-(phenylthio)propan-1-one (28403-86-3) → erythro-2-chloro-1-phenyl-2-phenylsulfonylpropanol (117841-12-0,117841-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / 30percent H₂O₂ / ammonium molybdate / methanol

2: 1.) NaH, 2.) NCS / 1.) toluene, 2.) toluene

3: NaBH₄, NaH₂PO₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / Ambient temperature

With sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; dihydrogen peroxide; sodium hydride; ammonium molybdate; In methanol; 1,2-dimethoxyethane; water;

upstream raw materials:

1-(1-chloroethyl)phenyl sulfone

benzaldehyde

1-chloroethyl phenyl sulfide

2-chloro-1-phenylpropan-1-one

Downstream raw materials:

cis-1-methyl-2-phenylepoxyethyl phenyl sulfone

Refernces