C₁₄⁽¹³⁾CH₁₆⁽²⁾H₃NO₃

Base Information

• Chemical Name: C₁₄⁽¹³⁾CH₁₆⁽²⁾H₃NO₃
• CAS No.: 1028386-89-1
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 265.286
• Mol file: 1028386-89-1.mol

Synonyms:

Chemical Property of C₁₄⁽¹³⁾CH₁₆⁽²⁾H₃NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₄⁽¹³⁾CH₁₆⁽²⁾H₃NO₃

There total 1 articles about C₁₄⁽¹³⁾CH₁₆⁽²⁾H₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2H3,13C]methylcopper + (4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone (90719-30-5) → C14(13)CH16(2)H3NO3 (1028386-89-1)

Guidance literature:

[²H₃,¹³C]methylcopper; (4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone; With trimethylsilyl iodide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 4h;

With pyridine; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Further stages.;

DOI:10.1002/jlcr.1223

Reference yield: 83.0%

1,3,5-Trioxan (110-88-3) + C14(13)CH16(2)H3NO3 (1028386-89-1) → C15(13)CH18(2)H3NO4 (1028386-90-4)

Guidance literature:

Multistep reaction.;

DOI:10.1002/jlcr.1223

Reference yield:

C14(13)CH16(2)H3NO3 (1028386-89-1) → C20(13)CH24(2)H3N3O4S (1028386-95-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: LiOH; H₂O₂ / tetrahydrofuran; H₂O / 20 °C

1.2: Na₂SO₃ / 0 - 5 °C

1.3: 88 percent / LiOH / H₂O / 65 °C

2.1: 92 percent / DIAD; PPh₃ / tetrahydrofuran / 2 h / 20 °C

3.1: 100 percent / thionyl chloride / CH₂Cl₂ / 20 °C

4.1: 90 percent / K₂CO₃ / CH₂Cl₂

With lithium hydroxide; thionyl chloride; di-isopropyl azodicarboxylate; dihydrogen peroxide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 3.1: Mitsunobu reaction;

DOI:10.1002/jlcr.1223

upstream raw materials:

(4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone

Downstream raw materials:

C₁₅⁽¹³⁾CH₁₈⁽²⁾H₃NO₄

C₂₀⁽¹³⁾CH₂₄⁽²⁾H₃N₃O₄S

Refernces