17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid

Base Information

• Chemical Name: 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid
• CAS No.: 10520-95-3
• Molecular Formula: C₂₅H₃₂O₅
• Molecular Weight: 412.526
• Mol file: 10520-95-3.mol

Synonyms:

Chemical Property of 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid

There total 5 articles about 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid (10520-95-3)

Guidance literature:

With acetic acid; ethyl acetate; Einleiten von Ozon; Behandeln der Reaktionsloesung mit wss. Wasserstoffperoxid;

DOI:10.1021/ja01157a147 DOI:10.1126/science.106.2750.248

Reference yield:

testosterone benzoate (2088-71-3) → 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid (10520-95-3)

Guidance literature:

With sodium periodate; ruthenium(III) chloride trihydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jacs.6b05788

Reference yield:

testosterone benzoate (2088-71-3) + acetic acid (64-19-7,77671-22-8) + ethyl acetate (141-78-6) → 17β-benzoyloxy-5-oxo-3,5-seco-A-nor-androstan-3-oic acid (10520-95-3)

Guidance literature:

Einleiten von Ozon; Behandeln der Reaktionsloesung mit wss. Wasserstoffperoxid;

DOI:10.1126/science.106.2750.248

upstream raw materials:

testosterone benzoate

acetic acid

ethyl acetate

Downstream raw materials:

4-thia-androsten-3,17-diol 17-benzoate

5-benzyloxy-4-oxa-5ξ-androstan-17β-ol

17β-benzoyloxy-4-thia-5-androsten-3-one

17β-benzoyloxy-4-oxa-androst-5-en-3-one

Refernces

• 1、 Liu, Zhao-Jing,Lu, Xi,Wang, Guan,Li, Lei,Jiang, Wei-Tao,Wang, Yu-Dong,Xiao, Bin,Fu, Yao. "Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C-N Bond Formation from Nonactivated Aliphatic Carboxylic Acids". supporting information. p. 9714 - 9719. Retrieved 2016/08/11.