Technology Process of [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(2-naphthalen-1-yl-ethylcarbamoyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester
There total 16 articles about [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(2-naphthalen-1-yl-ethylcarbamoyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / ethanol / 16 h / Heating
2: LiI / pyridine / 14 h / Heating
3: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating
4: aq. LiOH*H2O / ethanol / 7 h / 0 °C
5: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature
With
lithium hydroxide; TEA; diphenyl phosphoryl azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide;
In
1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z
- Guidance literature:
-
Multi-step reaction with 8 steps
1: NMM / tetrahydrofuran / 3 h / 0 °C
2: 62 percent / 2,6-lutidine / CH2Cl2 / 3 h / Ambient temperature
3: 96 percent / NaI / acetone / 16 h / Ambient temperature
4: 58 percent / DBU / dimethylformamide / 24 h / Ambient temperature
5: LiI / pyridine / 14 h / Heating
6: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating
7: aq. LiOH*H2O / ethanol / 7 h / 0 °C
8: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature
With
4-methyl-morpholine; 2,6-dimethylpyridine; lithium hydroxide; TEA; diphenyl phosphoryl azide; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm950684z
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / dimethylformamide / 3 h / 80 °C
2: 71 percent / ethanol / 16 h / Heating
3: LiI / pyridine / 14 h / Heating
4: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating
5: aq. LiOH*H2O / ethanol / 7 h / 0 °C
6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature
With
lithium hydroxide; TEA; diphenyl phosphoryl azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide;
In
1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z