Technology Process of (2-chloro-8-fluorodibenzo[b,d]thiophene-4,6-diyl)dimethanol
There total 5 articles about (2-chloro-8-fluorodibenzo[b,d]thiophene-4,6-diyl)dimethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sulfuric acid; copper; sodium nitrite;
In
water;
at 0 - 20 ℃;
for 3.16667h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; potassium carbonate / copper / 12 h / 90 °C
2.1: borane-THF / tetrahydrofuran / 20 °C
2.2: 16 h
3.1: hydrogenchloride; acetic acid; zinc / methanol; water / 20 °C
4.1: sulfuric acid; copper; sodium nitrite / water / 3.17 h / 0 - 20 °C / Heating / reflux
With
hydrogenchloride; borane-THF; sulfuric acid; water; copper; potassium carbonate; acetic acid; zinc; sodium nitrite;
copper;
In
tetrahydrofuran; methanol; water;
1.1: Ullmann Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; potassium carbonate / copper / 12 h / 90 °C
2.1: borane-THF / tetrahydrofuran / 20 °C
2.2: 16 h
3.1: hydrogenchloride; acetic acid; zinc / methanol; water / 20 °C
4.1: sulfuric acid; copper; sodium nitrite / water / 3.17 h / 0 - 20 °C / Heating / reflux
With
hydrogenchloride; borane-THF; sulfuric acid; water; copper; potassium carbonate; acetic acid; zinc; sodium nitrite;
copper;
In
tetrahydrofuran; methanol; water;
1.1: Ullmann Reaction;