4,5-DICHLORO-QUINOLINE

Base Information

• Chemical Name: 4,5-DICHLORO-QUINOLINE
• CAS No.: 21617-18-5
• Molecular Formula: C9H5Cl2N
• Molecular Weight: 198.051
• Hs Code.: 2933499090
• Mol file: 21617-18-5.mol

Synonyms:NSC 149794;4,5-Dichloro-quinoline;

Chemical Property of 4,5-DICHLORO-QUINOLINE

Chemical Property:

• Vapor Pressure: 0.00313mmHg at 25°C
• Melting Point: 118°C
• Refractive Index: 1.66
• Boiling Point: 292.9 °C at 760 mmHg
• PKA: 2.47±0.25(Predicted)
• Flash Point: 158.7 °C
• PSA: 12.89000
• Density: 1.407 g/cm³
• LogP: 3.54160
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Sligh

Purity/Quality:

99%, ^*data from raw suppliers

4,5-Dichloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5-Dichloroquinoline can be used as an antimalarial.

Technology Process of 4,5-DICHLORO-QUINOLINE

There total 5 articles about 4,5-DICHLORO-QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-aniline (108-42-9) → 4,5-dichloro-quinoline (21617-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / Erhitzen des Reaktionsprodukts in Paraffinoel auf 250grad

2: aqueous NaOH

3: mineral oil / 270 °C

4: phosphoryl chloride

With sodium hydroxide; acetic acid; mineral oil; trichlorophosphate;

DOI:10.1021/ja01205a036

Reference yield:

5-chloro-4-hydroxy-quinoline-2-carboxylic acid (35973-28-5) → 4,5-dichloro-quinoline (21617-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: mineral oil / 270 °C

2: phosphoryl chloride

With mineral oil; trichlorophosphate;

DOI:10.1021/ja01205a036

Reference yield:

5-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester (21640-98-2) → 4,5-dichloro-quinoline (21617-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NaOH

2: mineral oil / 270 °C

3: phosphoryl chloride

With sodium hydroxide; mineral oil; trichlorophosphate;

DOI:10.1021/ja01205a036

upstream raw materials:

5-chloro-4-hydroxyquinoline

5-chloro-4-hydroxy-quinoline-2-carboxylic acid

5-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

3-chloro-aniline

Downstream raw materials:

5-chloro-1-(2-chloro-benzyl)-4-iodo-quinolinium; iodide

N⁴,N⁴-diethyl-N¹-(5-chloro-[4]quinolyl)-1-methyl-butanediyldiamine

5-Chlor-4-amino-chinolin

4-benzyl-5-chloro-quinoline