C₁₆H₁₆N₄OS

Base Information

• Chemical Name: C₁₆H₁₆N₄OS
• CAS No.: 1437793-05-9
• Molecular Formula: C₁₆H₁₆N₄OS
• Molecular Weight: 312.395
• Mol file: 1437793-05-9.mol

Synonyms:

Chemical Property of C₁₆H₁₆N₄OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₆N₄OS

There total 5 articles about C₁₆H₁₆N₄OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-1,3-dihydro-2H-benzo[d]imidazole-2-thione (2818-66-8) + N-benzyl-2-bromoacetamide (2945-03-1) → C16H16N4OS (1437793-05-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 1h;

DOI:10.1002/cmdc.201300114

Reference yield:

1,2-diamino-benzene (95-54-5) → C16H16N4OS (1437793-05-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h / 20 °C

1.2: 0.25 h / 130 °C / Microwave irradiation

1.3: 1 h / 0 °C / pH 5

2.1: sulfuric acid; nitric acid / 1 h / -5 - 0 °C

3.1: iron; hydrogenchloride / ethanol; water / 0.75 h / 40 °C

4.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; nitric acid; iron; potassium hydroxide; In ethanol; water;

DOI:10.1002/cmdc.201300114

Reference yield:

2,3-dihydrobenzimidazol-2-thione (583-39-1,2080-59-3) → C16H16N4OS (1437793-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 1 h / -5 - 0 °C

2: iron; hydrogenchloride / ethanol; water / 0.75 h / 40 °C

3: potassium hydroxide / ethanol; water / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; nitric acid; iron; potassium hydroxide; In ethanol; water;

DOI:10.1002/cmdc.201300114

upstream raw materials:

1,2-diamino-benzene

2,3-dihydrobenzimidazol-2-thione

1,3-dihydro-5-nitro-2H-benzimidazole-2-thione

5-amino-1,3-dihydro-2H-benzo[d]imidazole-2-thione

Refernces