2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

Base Information

• Chemical Name: 2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid
• CAS No.: 837-83-2
• Molecular Formula: C10H17N3O4
• Molecular Weight: 243.263
• Hs Code.: 2933990090
• NSC Number: 97941
• DSSTox Substance ID: DTXSID901003703
• ChEMBL ID: CHEMBL1475451
• Mol file: 837-83-2.mol

Synonyms:NSC97941;NCIOpen2_006402;SCHEMBL3388723;CHEMBL1475451;GGLIDLCEPDHEJO-UHFFFAOYSA-N;DTXSID901003703;NSC-97941;NCGC00166282-01;N-[(1-Glycylpyrrolidin-2-yl)(hydroxy)methylidene]alanine;2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

Chemical Property of 2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 6.46E-15mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 579.1 °C at 760 mmHg
• Flash Point: 304 °C
• PSA: 112.73000
• Density: 1.33 g/cm³
• LogP: -0.44550
• Storage Temp.: −20°C
• Solubility.: Methanol (Slightly, Heated), Water (Slightly, Sonicated)
• XLogP3: -4.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 243.12190603
• Heavy Atom Count: 17
• Complexity: 332

Purity/Quality:

98%,99%, ^*data from raw suppliers

Gly-Pro-Ala-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(=O)O)NC(=O)C1CCCN1C(=O)CN
• Uses: H-Gly-Pro-Ala-OH is used in the preparation of preventive medicine improvement medicine of gingivitis.

Technology Process of 2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

There total 1 articles about 2-{[1-(2-Amino-acetyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-alanin (56-41-7,25191-17-7,18875-37-1) + H-Gly-Pro-pNA (60189-43-7) → 4-nitro-aniline (100-01-6,104810-17-5) + gly-pro-ala (837-83-2) + H-Gly-Pro-OH (704-15-4)

Guidance literature:

With dipeptidyl peptidase IV; In glycerol; at 40 ℃;

Reference yield:

gly-pro-ala (837-83-2) → L-alanin (56-41-7,25191-17-7,18875-37-1) + H-Gly-Pro-OH (704-15-4)

Guidance literature:

at 37 ℃; for 0.166667h; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR;

DOI:10.1271/bbb.56.704

upstream raw materials:

L-alanin

H-Gly-Pro-pNA

Downstream raw materials:

L-alanin

H-Gly-Pro-OH

Refernces