Pyridine, 2-(2,6-dimethylphenyl)-

Base Information

• Chemical Name: Pyridine, 2-(2,6-dimethylphenyl)-
• CAS No.: 10273-91-3
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Mol file: 10273-91-3.mol

Synonyms:

Chemical Property of Pyridine, 2-(2,6-dimethylphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-(2,6-dimethylphenyl)-

There total 19 articles about Pyridine, 2-(2,6-dimethylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-pyridine (109-04-6) + 2,6-dimethylbenzene boronic acid (100379-00-8) → 2-(2,6-dimethylphenyl)pyridine (10273-91-3)

Guidance literature:

With palladium diacetate; (1s,5s)-9-([1,1'-biphenyl]-2-yl)-9-phosphabicyclo-[3.3.1]nonane; potassium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/d1ra04947j

Reference yield: 89.0%

2,6-dimethyliodobenzene (608-28-6) + pyridine-2-boronic acid N-phenyldiethanolamine ester (882521-96-2) → 2-(2,6-dimethylphenyl)pyridine (10273-91-3)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; copper(l) iodide; In tetrahydrofuran; Heating;

DOI:10.1016/j.tetlet.2003.11.068

Reference yield: 89.0%

2-chloropyridine (109-09-1) + 2,6-dimethylbenzene boronic acid (100379-00-8) → 2-(2,6-dimethylphenyl)pyridine (10273-91-3)

Guidance literature:

With C₅₁H₄₀ClN₃O₅P₂Pd; sodium hydroxide; In water; at 80 ℃; for 11h; Catalytic behavior;

DOI:10.1002/ejic.201900781

upstream raw materials:

2,6-dimethyliodobenzene

pyridine-2-boronic acid N-phenyldiethanolamine ester

2-phenylpyridine

tetramethylstannane

Refernces

• 1、 Holzapfel, Cedric W.,Lamola, Jairus L.,Maumela, Munaka Christopher,Moshapo, Paseka T.. "Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions". . p. 26883 - 26891. Retrieved 2021/08/17.
• 2、 Ni, Shengjun,Hribersek, Matic,Baddigam, Swarna K.,Ingner, Fredric J. L.,Orthaber, Andreas,Gates, Paul J.,Pilarski, Lukasz T.. "Mechanochemical Solvent-Free Catalytic C?H Methylation". supporting information. p. 6660 - 6666. Retrieved 2020/12/18.