N-PHTHALOYL-DL-METHIONINE

Base Information

• Chemical Name: N-PHTHALOYL-DL-METHIONINE
• CAS No.: 52881-96-6
• Molecular Formula: C₁₃H₁₃NO₄S
• Molecular Weight: 279.317
• Mol file: 52881-96-6.mol

Synonyms:2-Isoindolineaceticacid, a-[2-(methylthio)ethyl]-1,3-dioxo-(6CI,7CI,8CI);1,3-Dihydro-1,3-dioxo-a-(2-methylthioethyl)-2H-isoindole-2-acetic acid;N-Phthaloyl-DL-methionine;N-[1-Carboxy-3-(methylthio)propyl]phthalimide;NSC15852;

Chemical Property of N-PHTHALOYL-DL-METHIONINE

Chemical Property:

• Vapor Pressure: 1.7E-10mmHg at 25°C
• Boiling Point: 492 °C at 760 mmHg
• Flash Point: 251.4 °C
• PSA: 99.98000
• Density: 1.422g/cm³
• LogP: 1.42680
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(1,3-Dioxoisoindolin-2-yl)-4-(methylthio)butanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-PHTHALOYL-DL-METHIONINE

There total 2 articles about N-PHTHALOYL-DL-METHIONINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) + DL-methionine (59-51-8,26062-47-5,58576-49-1) → 1,3-dihydro-1,3-dioxo-α(CH2CH2SCH3)-2H-isoindole-2-acetate (5464-44-8,29588-91-8,52881-96-6)

Guidance literature:

at 185 ℃;

Reference yield:

→ 1,3-dihydro-1,3-dioxo-α(CH2CH2SCH3)-2H-isoindole-2-acetate (5464-44-8,29588-91-8,52881-96-6)

Guidance literature:

N-Ethoxycarbonyl-phthalimid, DL-Methionin, wss. Na2CO3, Raumtemp.;

Reference yield:

diphenylketene-N-p-tolylimine (5110-45-2,73940-93-9) + 1,3-dihydro-1,3-dioxo-α(CH2CH2SCH3)-2H-isoindole-2-acetate (5464-44-8,29588-91-8,52881-96-6) → N,N-phthaloyl-methionine-(N-diphenylacetyl-p-toluidide) (120831-43-8)

Guidance literature:

With tetrahydrofuran;

DOI:10.1021/ja01548a060

upstream raw materials:

phthalic anhydride

DL-methionine

Downstream raw materials:

N,N-phthaloyl-methionine-(N-diphenylacetyl-p-toluidide)

methyl-(S)-2-phthalimido-4-methylthiobutanoate

methyl 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropanecarboxylate

methyl (S)-4-methylsulfanyl-2-phthalimidobutanoate

Refernces

• 1、 Dobrydnev, Alexey V.,Popova, Maria V.,Saffon-Merceron, Nathalie,Listunov, Dymytrii,Volovenko, Yulian M.. "Synthesis of the First Representatives of Spiro-1λ6-isothiazolidine-1,1,4-triones". . p. 2523 - 2528. Retrieved 2015/09/01.