Benzeneethanimidothioic acid, N-hydroxy-a-oxo-, 2-(diethylamino)ethyl ester

Base Information

• Chemical Name: Benzeneethanimidothioic acid, N-hydroxy-a-oxo-, 2-(diethylamino)ethyl ester
• CAS No.: 102941-46-8
• Molecular Formula: C₁₄H₂₀N₂O₂S
• Molecular Weight: 280.391
• Mol file: 102941-46-8.mol

Synonyms:

Chemical Property of Benzeneethanimidothioic acid, N-hydroxy-a-oxo-, 2-(diethylamino)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanimidothioic acid, N-hydroxy-a-oxo-, 2-(diethylamino)ethyl ester

There total 4 articles about Benzeneethanimidothioic acid, N-hydroxy-a-oxo-, 2-(diethylamino)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetophenone (98-86-2) → S-2-(N,N-diethylamino)ethyl benzoylthioformohydroximate (102941-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl nitrite, HCl(gas)

2: NaOCH₃ / propan-2-ol / Ambient temperature

With hydrogenchloride; i-propyl nitrite; sodium methylate; In isopropyl alcohol;

DOI:10.1021/jm00159a021

Reference yield:

acetophenone (98-86-2) → N-Hydroxy-2-oxo-2-phenyl-thioacetimidic acid 2-diethylamino-ethyl ester (102941-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / HCl

2: triethylamine / CHCl₃ / 4 h / Ambient temperature

With hydrogenchloride; triethylamine; In chloroform;

DOI:10.1021/jm00142a003

Reference yield:

N-hydroxy-2-oxo-2-phenylethanimidoyl chloride (4937-87-5) + 2-(diethylamino)ethanethiol hydrochloride (1942-52-5) → N-Hydroxy-2-oxo-2-phenyl-thioacetimidic acid 2-diethylamino-ethyl ester (102941-46-8)

Guidance literature:

With triethylamine; In chloroform; for 4h; Ambient temperature;

DOI:10.1021/jm00142a003

upstream raw materials:

N-hydroxy-2-oxo-2-phenylethanimidoyl chloride

2-(diethylamino)ethanethiol hydrochloride

acetophenone

(Z)-N-hydroxy-α-oxobenzeneethanimidoyl chloride

Refernces

• 1、 Kenley,Howd,Mosher,Winterle. "Nonquaternary cholinesterase reactivators. Dialkylaminoalkyl thioesters of α-ketothiohydroximic acids as reactivators of diisopropyl phosphorofluoridate inhibited acetylcholinesterase". . p. 1124 - 1133. Retrieved 2007/10/02.