Technology Process of 8-(2,5-dihexyl-4'-methoxy-biphenyl-4-yl)-isoquinolin-3-ol
There total 9 articles about 8-(2,5-dihexyl-4'-methoxy-biphenyl-4-yl)-isoquinolin-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 94 percent / imidazole / dimethylformamide / 12 h / 20 °C
2.1: barium hydroxide octahydrate; tetrakis(triphenylphosphane)palladium(0) / 1,2-dimethoxy-ethane; H2O / Heating
2.2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.5 h
With
1H-imidazole; tetrakis(triphenylphosphine) palladium(0); barium hydroxide octahydrate;
In
1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
2.1: Suzuki coupling;
DOI:10.1002/ejoc.200600796
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 64 percent / conc. sulfuric acid / 16 h / 20 °C
2.1: 94 percent / imidazole / dimethylformamide / 12 h / 20 °C
3.1: barium hydroxide octahydrate; tetrakis(triphenylphosphane)palladium(0) / 1,2-dimethoxy-ethane; H2O / Heating
3.2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.5 h
With
1H-imidazole; tetrakis(triphenylphosphine) palladium(0); barium hydroxide octahydrate; sulfuric acid;
In
1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
3.1: Suzuki coupling;
DOI:10.1002/ejoc.200600796
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; petroleum ether / 2 h / -78 °C
1.2: 100 percent / trimethyl borate / tetrahydrofuran; petroleum ether / 20 °C
2.1: barium hydroxide octahydrate; tetrakis(triphenylphosphane)palladium(0) / 1,2-dimethoxy-ethane; H2O / Heating
2.2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.5 h
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; barium hydroxide octahydrate;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; Petroleum ether;
2.1: Suzuki coupling;
DOI:10.1002/ejoc.200600796