3-fluoro-DL-PhTX-343

Base Information

• Chemical Name: 3-fluoro-DL-PhTX-343
• CAS No.: 144117-53-3
• Molecular Formula: C₂₃H₄₀FN₅O₃
• Molecular Weight: 453.601
• Mol file: 144117-53-3.mol

Synonyms:

Chemical Property of 3-fluoro-DL-PhTX-343

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-DL-PhTX-343

There total 5 articles about 3-fluoro-DL-PhTX-343 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Spermine (71-44-3) + N-butyryl-3-fluoro-DL-tyrosine p-nitrophenyl ester (144117-52-2) → 3-fluoro-DL-PhTX-343 (144117-53-3)

Guidance literature:

In tetrahydrofuran; methanol; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81575-1

Reference yield:

3-fluoro-DL-tyrosine (403-90-7) → 3-fluoro-DL-PhTX-343 (144117-53-3)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / dioxane; H₂O / 12 h / Ambient temperature

2: DCC / ethyl acetate / 2 h / Ambient temperature

3: TFA / CH₂Cl₂ / 2 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 55 percent / methanol; tetrahydrofuran / 3 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

DOI:10.1016/S0040-4020(01)81575-1

Reference yield:

N-Boc-3-fluorotyrosine (125218-33-9,221077-78-7) → 3-fluoro-DL-PhTX-343 (144117-53-3)

Guidance literature:

Multi-step reaction with 4 steps

1: DCC / ethyl acetate / 2 h / Ambient temperature

2: TFA / CH₂Cl₂ / 2 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 55 percent / methanol; tetrahydrofuran / 3 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

DOI:10.1016/S0040-4020(01)81575-1

upstream raw materials:

Spermine

N-butyryl-3-fluoro-DL-tyrosine p-nitrophenyl ester

3-fluoro-DL-tyrosine

N-Boc-3-fluorotyrosine

Refernces